Overcoming barriers to radiopharmaceutical therapy (RPT): An overview from the NRG-NCI Working Group on dosimetry of radiopharmaceutical therapy Review


Authors: Divgi, C.; Carrasquillo, J. A.; Meredith, R.; Seo, Y.; Frey, E. C.; Bolch, W. E.; Zimmerman, B. E.; Akabani, G.; Jacobson, D. A.; Brown, B.; Davern, S. M.; Hobbs, R. F.; Humm, J.; Moros, E. G.; Morse, D.; Papineni, R.; Zanzonico, P.; Benedict, S. H.; Sgouros, G.
Review Title: Overcoming barriers to radiopharmaceutical therapy (RPT): An overview from the NRG-NCI Working Group on dosimetry of radiopharmaceutical therapy
Abstract: Radiopharmaceutical therapy (RPT) continues to demonstrate tremendous potential in improving the therapeutic gains in radiation therapy by specifically delivering radiation to tumors that can be well assessed in terms of dosimetry and imaging. Dosimetry in external beam radiation therapy is standard practice. This is not the case, however, in RPT. This NRG (acronym formed from the first letter of the 3 original groups: National Surgical Adjuvant Breast and Bowel Project, the Radiation Therapy Oncology Group, and the Gynecologic Oncology Group)-National Cancer Institute Working Group review describes some of the challenges to improving RPT. The main priorities for advancing the field include (1) developing and adopting best practice guidelines for incorporating patient-specific dosimetry for RPT that can be used at both large clinics with substantial resources and more modest clinics that have limited resources, (2) establishing and improving strategies for introducing new radiopharmaceuticals for clinical investigation, (3) developing approaches to address the radiophobia that is associated with the administration of radioactivity for cancer therapy, and (4) solving the financial and logistical issues of expertise and training in the developing field of RPT. © 2020
Keywords: radiotherapy; oncology; cancer therapy; dosimetry; radiation therapy oncology groups; diseases; clinical investigation; external beam radiation therapy; national cancer institute; patient specific; standard practices; best practice guidelines
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Volume: 109
Issue: 4
ISSN: 0360-3016
Publisher: Elsevier Inc.  
Date Published: 2021-03-15
Start Page: 905
End Page: 912
Language: English
DOI: 10.1016/j.ijrobp.2020.12.002
PUBMED: 33309909
PROVIDER: scopus
PMCID: PMC8399328
DOI/URL:
Notes: Review -- Export Date: 1 March 2021 -- Source: Scopus
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MSK Authors
  1. John Laurence Humm
    420 Humm
  2. Pat B Zanzonico
    344 Zanzonico