Prognostic implications of depression and inflammation in patients with metastatic lung cancer Journal Article

   


Authors: McFarland, D. C.; Saracino, R. M.; Miller, A. H.; Breitbart, W.; Rosenfeld, B.; Nelson, C.
Article Title: Prognostic implications of depression and inflammation in patients with metastatic lung cancer
Abstract: Background: Lung cancer-related inflammation is associated with depression. Both elevated inflammation and depression are associated with worse survival. However, outcomes of patients with concomitant depression and elevated inflammation are not known. Materials & methods: Patients with metastatic lung cancer (n = 123) were evaluated for depression and inflammation. Kaplan-Meier plots and Cox proportional hazard models provided survival estimations. Results: Estimated survival was 515 days for the cohort and 323 days for patients with depression (hazard ratio: 1.12; 95% CI: 1.05-1.179), 356 days for patients with elevated inflammation (hazard ratio: 2.85, 95% CI: 1.856-4.388), and 307 days with both (χ2 = 12.546; p < 0.001]). Conclusion: Depression and inflammation are independently associated with inferior survival. Survival worsened by inflammation is mediated by depression-a treatable risk factor. © 2020 Future Medicine Ltd.
Keywords: survival; cancer survival; treatment outcome; aged; major clinical study; cancer patient; c reactive protein; protein blood level; inflammation; cohort analysis; lung cancer; c-reactive protein; risk factor; depression; lung metastasis; immune response; clinical evaluation; depressive symptoms; cancer prognosis; immune function; prognosis; human; male; female; priority journal; article
Journal Title: Future Oncology
Volume: 17
Issue: 2
ISSN: 1479-6694
Publisher: Future Medicine  
Date Published: 2021-01-01
Start Page: 183
End Page: 196
Language: English
DOI: 10.2217/fon-2020-0632
PUBMED: 33305608
PROVIDER: scopus
PMCID: PMC7857340
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099866023&doi=10.2217%2ffon-2020-0632&partnerID=40&md5=b2e993831272516c168fb7c1edbaf84f
Notes: Article -- Export Date: 1 March 2021 -- Source: Scopus
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MSK Authors
  1. William S Breitbart
    504 Breitbart
  2. Christian Nelson
    387 Nelson
  3. Rebecca Mary James
    77 James
  4. Daniel C. McFarland
    70 McFarland
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