Graft rejection in recipients of T-cell-depleted HLA-nonidentical marrow transplants for leukemia: Identification of host-derived antidonor allocytotoxic T lymphocytes Journal Article

  

Authors:	Kernan, N. A.; Flomenberg, N.; Dupont, B.; O’Reilly, R. J.
Article Title:	Graft rejection in recipients of T-cell-depleted HLA-nonidentical marrow transplants for leukemia: Identification of host-derived antidonor allocytotoxic T lymphocytes
Abstract:	Clinical trials with bone marrow depleted of donor T lymphocytes indicate that both the incidence and severity of graft-versus-host disease (GVHD) in patients undergoing bone marrow transplantation (BMT) for treatment of leukemia are greatly reduced. However, there has been a concurrent increase in the incidence of graft rejection, particularly among recipients of HLA-nonidentical marrow grafts. In order to investigate the nature of graft failure, peripheral blood mononuclear cells (PBMC) present at the time of graft failure have been characterized by phenotypic and functional analyses in 5 recipients of HLA-nonidentical marrow grafts. Rejection of HLA-nonidentical marrow grafts was associated with the emergence of host-derived T lymphocytes in all 5 patients. In 3 of these patients, the cells could be tested directly for cell-mediated cytotoxicity. Antidonor cytotoxicity was detected in each of these 3 patients. In one patient the target specificity of the cytotoxic lymphocytes was identified as the donor class I HLA antigen, HLA-B7. None of the patient PBMC mediated cytotoxicity against the natural killer cell target K562. © 1987 by The Williams and Wilkins Co.
Keywords:	leukemia; human cell; t-lymphocytes; phenotype; leukemia, myeloid; cytotoxic t lymphocyte; t-lymphocytes, cytotoxic; graft versus host reaction; natural killer cell; graft rejection; monocytes; bone marrow transplantation; therapy; hla antigens; clinical trials; leukemia, lymphocytic; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; blood and hemopoietic system
Journal Title:	Transplantation
Volume:	43
Issue:	6
ISSN:	0041-1337
Publisher:	Lippincott Williams & Wilkins
Date Published:	1987-06-01
Start Page:	842
End Page:	847
Language:	English
DOI:	10.1097/00007890-198743060-00014
PUBMED:	3296349
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023189896&doi=10.1097%2f00007890-198743060-00014&partnerID=40&md5=9db7112cf863f39c2606bcd2be6dc91e
Notes:	Article -- Export Date: 5 February 2021 -- Source: Scopus

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