Results of surgical treatment of stage III lung cancer invading the mediastinum Journal Article
| Authors: | Burt, M. E.; Pomerantz, A. H.; Bains, M. S.; McCormack, P. M.; Kaiser, L. R.; Hilaris, B. S.; Martini, N. |
| Article Title: | Results of surgical treatment of stage III lung cancer invading the mediastinum |
| Abstract: | From 1974 to 1984, 225 patients underwent thoracotomy at Memorial Sloan-Kettering Cancer Center for primary non-small cell lung cancer invading only the mediastinum (T3). The perioperative mortality was 2.7 per cent, and the nonfatal complication rate 13 per cent. Forty-nine patients underwent complete resection of all intrathoracic disease, with a median survival of 17 months, 3-year survival of 21 per cent, and 5-year survival of 9 per cent. Thirty-three patients underwent pulmonary resection with simultaneous iodine-125 interstitial implantation or iridium-192 delayed afterloading to areas of unresectable primary or nodal disease, with a median survival of 12 months, 3-year survival of 22 per cent, and 5-year survival of 22 per cent. One hundred and one patients underwent interstitial implantation without resection, with a median survival of 11 months, 3-year survival of 9 per cent, and no 5-year survivors. Forty-two patients had incomplete resection without intraoperative radiation therapy and fared no better than a cohort group of 44 unoperated patients with clinical evidence of mediastinal invasion - both groups had a median survival of 8 months and no 3-year survivors. An aggressive surgical approach with pulmonary resection and/or brachytherapy appears to offer some survival advantage to this group of patients. In particular, 5-year survival rates ranging from 7 to 15 per cent were observed in subsets of intraoperatively treated patients with invasion of pulmonary vein, phrenic nerve, esophagus, or pericardium and in those with clinically occult T3 disease. |
| Keywords: | survival; adult; aged; major clinical study; cancer staging; methodology; lung cancer; diagnosis; surgery; therapy; mediastinum metastasis; respiratory system; human |
| Journal Title: | Surgical Clinics of North America |
| Volume: | 67 |
| Issue: | 5 |
| ISSN: | 0039-6109 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1987-10-01 |
| Start Page: | 987 |
| End Page: | 1000 |
| Language: | English |
| DOI: | 10.1016/s0039-6109(16)44337-9 |
| PUBMED: | 2820072 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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