Changes in the levels of CD4(+) and CD8(+) T-lymphocytes after strontium-89 chloride therapy for painful bone metastases in patients correlate with treatment efficacy Journal Article
| Authors: | Li, Y.; Li, X. F.; Ma, Y.; Fang, N.; Russell, J.; Ma, D.; Sun, X.; Han, X.; Yang, H.; Kinuya, S. |
| Article Title: | Changes in the levels of CD4(+) and CD8(+) T-lymphocytes after strontium-89 chloride therapy for painful bone metastases in patients correlate with treatment efficacy |
| Abstract: | The aim of this study was to evaluate changes in the peripheral blood CD4+ and CD8+ T-lymphocyte populations following strontium-89 chloride (89SrCl2) therapy for painful bone metastases and to relate these changes to a therapeutic response. Forty-two (42) patients with painful bone metastases were treated with 148 MBq (4 mCi) of 89SrCl2. Blood samples were drawn before and monthly for 6 months after the treatment. CD4+ and CD8+ T-lymphocyte levels were measured using flow cytometry. The number of bone metastases and the pain score were used to assess the effect of therapy. Before the administration of 89SrCl 2, the ratio of CD4+ to CD8+ T-lymphocytes was lower in patients with bone metastases than in the control subjects (p < 0.01); after therapy, the ratio increased up to the fourth month and then gradually declined to pretreatment levels. Responders had higher post-therapeutic ratios of CD4+ to CD 8+ than nonresponders. There was a good correlation between the ratio of CD4+ to CD8+ and both the number of bone metastases and the pain score. The ratio of CD 4+ to CD8+ T-lymphocytes correlated strongly with the response of bone metastases to 89SrCl2, and therefore, may be used as an indicator of 89SrCl2 efficacy. © Mary Ann Liebert, Inc. |
| Keywords: | adult; clinical article; treatment outcome; bone neoplasms; middle aged; unclassified drug; drug efficacy; bone metastasis; flow cytometry; cd8+ t lymphocyte; cd8-positive t-lymphocytes; pain; radiotherapy dosage; bone pain; cancer pain; breast neoplasms; correlation analysis; cd4+ t lymphocyte; cd4-positive t-lymphocytes; reference values; scoring system; pain assessment; lymphocyte count; whole-body irradiation; bone metastases; strontium 89; cd4+ to cd8+ ratio; cd4+ t-lymphocytes; cd8+ t-lymphocytes; strontium-89 chloride; strontium chloride; strontium chloride sr 89; strontium radioisotopes |
| Journal Title: | Cancer Biotherapy and Radiopharmaceuticals |
| Volume: | 22 |
| Issue: | 3 |
| ISSN: | 1084-9785 |
| Publisher: | Mary Ann Liebert, Inc |
| Date Published: | 2007-01-01 |
| Start Page: | 367 |
| End Page: | 373 |
| Language: | English |
| DOI: | 10.1089/cbr.2007.372.A |
| PUBMED: | 17651042 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: CBRAF" - "Source: Scopus" |
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