Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene Journal Article
| Authors: | Sorrentino, V.; Drozdoff, V.; Zeitz, L.; Fleissner, E. |
| Article Title: | Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene |
| Abstract: | C3H/10T 1/2 cells were infected with a retroviral vector expressing a mouse c-my oncogene and a drug-selection marker. The resulting cells, morphologically indistinguishable from C3H/10T 1/2 , displayed a greatly enhanced sensitivity to neoplastic transformation by ionizing radiation or by a chemical carcinogen. Constitutive expression of myc therefore appears to synergize with an initial carcinogenic event, providing a function analogous to a subsequent event that apparently is required for the neoplastic transformation of these cells. This cell system should prove useful in exploring early stages in radiation-induced transformation. |
| Keywords: | priority journal |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 84 |
| Issue: | 12 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1987-06-01 |
| Start Page: | 4131 |
| End Page: | 4134 |
| Language: | English |
| DOI: | 10.1073/pnas.84.12.4131 |
| PUBMED: | 3473497 |
| PROVIDER: | scopus |
| PMCID: | PMC305037 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
