Neoplastic transformation dose response of oncogene-transfected rat embryo cells by gamma rays or 6 MeV alpha particles Journal Article
| Authors: | Ling, C. C.; Weiss, H.; Strauss, A.; Endlich, B.; Sheh, Y.; Wei, J. X.; Orazem, J. |
| Article Title: | Neoplastic transformation dose response of oncogene-transfected rat embryo cells by gamma rays or 6 MeV alpha particles |
| Abstract: | We measured a dose-response relationship for induction of neoplastic transformation by 6 MeV α particles and 137Cs γ rays in REC:myc and REC:ras cells, that is, rat embryo cells (REC) transfected with the c-myc or the Ha-ras oncogenes. The 6 MeV α particles simulated 222Rn emissions for risk assessment relative to low-LET radiations. The dose of γ rays was approximately twice that of α particles for a neoplastic transformation frequency of 10-3. The survival of the REC cells containing oncogenes was comparable to that of the commonly used C3H 10T1/2 cells for the same dose, but the former were more refractory to radiation-induced neoplastic transformation. Neoplastic transformation frequency measured in REC cells was 3 times lower than those typically measured in C3H 10T1/2 cells at a γ-ray dose of 6 Gy, and 5-10 times lower at an α-particle dose of 3 Gy. |
| Keywords: | dose response; nonhuman; animal cell; cell survival; carcinogenesis; animalia; oncogene; genetic transfection; dosimetry; cell transformation; rat; alpha radiation; gamma radiation; cesium 137; cancer; priority journal; article; radon 222 |
| Journal Title: | Radiation Research |
| Volume: | 138 |
| Issue: | 1 |
| ISSN: | 0033-7587 |
| Publisher: | Radiation Research Society |
| Date Published: | 1994-04-01 |
| Start Page: | 79 |
| End Page: | 85 |
| Language: | English |
| DOI: | 10.2307/3578849 |
| PROVIDER: | scopus |
| PUBMED: | 8146303 |
| DOI/URL: |
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