Neoplastic transformation dose response of oncogene-transfected rat embryo cells by gamma rays or 6 MeV alpha particles Journal Article


Authors: Ling, C. C.; Weiss, H.; Strauss, A.; Endlich, B.; Sheh, Y.; Wei, J. X.; Orazem, J.
Article Title: Neoplastic transformation dose response of oncogene-transfected rat embryo cells by gamma rays or 6 MeV alpha particles
Abstract: We measured a dose-response relationship for induction of neoplastic transformation by 6 MeV α particles and 137Cs γ rays in REC:myc and REC:ras cells, that is, rat embryo cells (REC) transfected with the c-myc or the Ha-ras oncogenes. The 6 MeV α particles simulated 222Rn emissions for risk assessment relative to low-LET radiations. The dose of γ rays was approximately twice that of α particles for a neoplastic transformation frequency of 10-3. The survival of the REC cells containing oncogenes was comparable to that of the commonly used C3H 10T1/2 cells for the same dose, but the former were more refractory to radiation-induced neoplastic transformation. Neoplastic transformation frequency measured in REC cells was 3 times lower than those typically measured in C3H 10T1/2 cells at a γ-ray dose of 6 Gy, and 5-10 times lower at an α-particle dose of 3 Gy.
Keywords: dose response; nonhuman; animal cell; cell survival; carcinogenesis; animalia; oncogene; genetic transfection; dosimetry; cell transformation; rat; alpha radiation; gamma radiation; cesium 137; cancer; priority journal; article; radon 222
Journal Title: Radiation Research
Volume: 138
Issue: 1
ISSN: 0033-7587
Publisher: Radiation Research Society  
Date Published: 1994-04-01
Start Page: 79
End Page: 85
Language: English
DOI: 10.2307/3578849
PROVIDER: scopus
PUBMED: 8146303
DOI/URL:
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MSK Authors
  1. C Clifton Ling
    323 Ling