Intraoperative radiation therapy for colorectal cancer Journal Article

  


Author: Cohen, A. M.
Article Title: Intraoperative radiation therapy for colorectal cancer
Abstract: There is a subset of patients with locally advanced rectal cancer whose tumors have not spread outside the pelvis. Aggressive local treatment combining high-dose radiation therapy with an extirpative operation can translate into a high degree of local control and cure. Damage to normal structures, however, particularly the small intestine, limits the radiation dose given by external beam x-rays. Intraoperative radiation therapy is used as a boost technique to the area of high risk or to gross residual cancer to improve the therapeutic ratio of such approaches. The entire pelvis is treated pre- or postoperatively with standard external radiation. Techniques of intraoperative radiation therapy involve both beams and implants. Permanent iodine-125 seeds or temporary irradium-192 implants can be used. Beam techniques involve low-dose x-rays or high-energy electron beams. An experience with 31 patients with primary rectal cancer treated at the Massachusetts General Hospital indicated the efficacy of such an approach. The patients received 5040 rads preoperatively. Four to 6 weeks later, they underwent surgical resection with electron beam radiation therapy. A 4-year local control rate of 92% was obtained in the 19 patients whose previously inoperable tumors were amenable to resection after the preoperative radiation. The actuarial survival rate at 4 years was 54%.
Keywords: review; colorectal cancer; short survey; therapy; intraoperative radiotherapy; large intestine; human; fast electron radiation
Journal Title: Problems in General Surgery
Volume: 4
Issue: 1
ISSN: 0739-8328
Publisher: Lippincott Williams & Wilkins  
Date Published: 1987-01-01
Start Page: 76
End Page: 82
Language: English
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023237985&partnerID=40&md5=059e21e41fbb3d39ee10912087a026fd
Notes: Article -- Export Date: 5 February 2021 -- Source: Scopus