5-substituted 2'-fluoro-arabinonucleosides as potential antiviral agents Journal Article
| Authors: | Huang, J. T.; Schinazi, R. F.; Gadler, H.; Price, R. W.; Su, T. L.; Watanabe, K. A. |
| Article Title: | 5-substituted 2'-fluoro-arabinonucleosides as potential antiviral agents |
| Abstract: | In order to study the electronic effects of 5-substituents of 2'-fluoro-ara-U on antiviral activity, eight nucleosides were synthesized and screened for their activity. Preliminary in vitro studies revealed that 5-thiocyano-, 5-hydroxy- and 5-formyl-ara-U are moderately active against HSV-1, HSV-2 and VZV, but they are also cytotoxic. None of these showed significant activity against CMV. |
| Keywords: | animal; animals; drug effect; drug screening; drug evaluation, preclinical; structure activity relation; structure-activity relationship; drug derivative; uracil arabinoside; simplexvirus; arabinofuranosyluracil; antivirus agent; herpes simplex virus; synthesis; uridine; vero cell; vero cells; antiviral agents; virus culture; vesicular stomatitis virus; plaque assay; humans; human; article; vesicular stomatitis-indiana virus |
| Journal Title: | Nucleic Acids Symposium Series |
| Issue: | 18 |
| ISSN: | 0261-3166 |
| Publisher: | Oxford University Press |
| Date Published: | 1987-01-01 |
| Start Page: | 261 |
| End Page: | 264 |
| Language: | English |
| PUBMED: | 2827131 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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