Intensity-modulated radiation therapy in the treatment of head and neck cancer involving the base of the skull Journal Article
| Author: | Lee, N. Y. |
| Article Title: | Intensity-modulated radiation therapy in the treatment of head and neck cancer involving the base of the skull |
| Abstract: | Tumors invading the skull base pose a difficult problem for the treating radiation oncologist. When confronting these highly complex tumors where the gross tumor abuts the optic apparatus or brain stem, the physician often has to make a difficult choice regarding coverage of the tumor, i.e., underdosing portions of the tumor to protect the critical normal tissues versus accepting the risk of late complication while ensuring full coverage of the tumor. This situation is often encountered in advanced T4 disease originating either in the paranasal sinuses or the nasopharynx. In this case report, the author presents a case in which difficult decisions were made when treating a complex, locally advanced, T4 nasopharyngeal cancer that invaded the skull base. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | adult; treatment outcome; case report; intensity modulated radiation therapy; carcinoma, squamous cell; cisplatin; fluorouracil; advanced cancer; cancer combination chemotherapy; drug withdrawal; multimodality cancer therapy; treatment planning; adjuvant therapy; cancer adjuvant therapy; cancer radiotherapy; combined modality therapy; drug megadose; nuclear magnetic resonance imaging; positron emission tomography; carboplatin; computer assisted tomography; multiple cycle treatment; tumor volume; mucosa inflammation; antineoplastic combined chemotherapy protocols; radiotherapy dosage; radiotherapy; oncology; cancer invasion; disease severity; brain; temporal lobe; head and neck cancer; imrt; tumors; radiotherapy, intensity-modulated; dosimetry; radiation dose fractionation; patient compliance; nasopharynx carcinoma; neoplasm invasiveness; headache; skull base; skull base neoplasms; drug substitution; nasopharyngeal neoplasms; epistaxis; head and neck; skull cancer; lymphadenopathy; diseases; blurred vision; nose obstruction; nasopharyngeal cancer; sinusitis; nose congestion; base of skull; complex anatomy; otalgia |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 69 |
| Issue: | 2 Suppl. |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-10-01 |
| Start Page: | S43 |
| End Page: | S45 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2007.05.064 |
| PUBMED: | 17848292 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: IOBPD" - "Source: Scopus" |
