Effect of 9-(1,3-dihydroxy-2-propoxymethyi)guanine and recombinant human β interferon alone and in combination on simian varicella virus infection in monkeys Journal Article
| Authors: | Soike, K. F.; Eppstein, D. A.; Gloff, C. A.; Cantrell, C.; Chou, T. C.; Gerone, P. J. |
| Article Title: | Effect of 9-(1,3-dihydroxy-2-propoxymethyi)guanine and recombinant human β interferon alone and in combination on simian varicella virus infection in monkeys |
| Abstract: | Treatment of viral infections with combinations of antiviral agents may permit administration of reduced doses of either or both drugs. Lowered doses may reduce associated toxicity. Intravenous administration of substantial doses of either human recombinant β interferon (rHuIFN-β) or 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) prevents development of simian varicella virus infection in African green monkeys. Daily doses of 2 × 106 U of rHuIFN-β/kg inhibited clinical disease in monkeys inoculated with simian varicella virus, and doses of DHPG between 20 and 60 mg/kg per day were necessary for similar antiviral effects. Intravenous administration of combinations of rHuIFN-β and DHPG permitted an ∼100-fold reduction in the effective dose of rHuIFN-β and a 10-fold reduction in the effective dose of DHPG. Analysis of data relating to viremia by using the method of the median-effect principle showed the combination of rHuIFN-β and DHPG was strongly synergistic in treatment of this infection. © 1987 by The University of Chicago. |
| Keywords: | nonhuman; animal; animal experiment; cercopithecus aethiops; time factors; drug mechanism; drug therapy, combination; recombinant proteins; antivirus agent; monkey; software; beta interferon; ganciclovir; therapy; chickenpox; acyclovir; antiviral agents; experimental infection; viremia; interferon type i; varicella zoster virus; antibodies, viral; herpesvirus 3, human; drug mixture; support, u.s. gov't, p.h.s. |
| Journal Title: | Journal of Infectious Diseases |
| Volume: | 156 |
| Issue: | 4 |
| ISSN: | 0022-1899 |
| Publisher: | Oxford University Press |
| Date Published: | 1987-10-01 |
| Start Page: | 607 |
| End Page: | 614 |
| Language: | English |
| DOI: | 10.1093/infdis/156.4.607 |
| PUBMED: | 3040868 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
