Inhibition of Simian varicella virus infection of monkeys by 1-(2-deoxy-2-fluoro-1-β-d-arabinofuranosyl)-5-ethyluracil (FEAU) and synergistic effects of combination with human recombinant interferon-β Journal Article

  

Authors:	Soike, K. F.; Chou, T. C.; Fox, J. J.; Watanabe, K. A.; Gloff, C. A.
Article Title:	Inhibition of Simian varicella virus infection of monkeys by 1-(2-deoxy-2-fluoro-1-β-d-arabinofuranosyl)-5-ethyluracil (FEAU) and synergistic effects of combination with human recombinant interferon-β
Abstract:	1-(2-Deoxy-2-fluoro-1-β-d-arabinofuranosyl)-5-ethyluracil (FEAU) has been shown to be a highly effective inhibitor of Simian varicella virus infection in African green monkeys. Administration of FEAU by either intravenous injection or gavage at doses as low as 1 mg/kg/day prevented the development of rash and reduced viremia. The effective dose could be further reduced to 0.2 mg/kg/day when administered in combination with a sub-effective dose of human recombinant interferon-β. No evidence of toxicity was seen in monkeys treated for 10 days with FEAU doses of 10 mg/kg/day when they were monitored by hematology and clinical chemistry tests and by clinical observations. © 1990.
Keywords:	nonhuman; comparative study; animal; animal experiment; dose-response relationship, drug; cercopithecus aethiops; animalia; drug synergism; herpesviridae; arabinofuranosyluracil; virus infection; monkey; herpes; uridine; injections, intravenous; feau; oral drug administration; antiviral agents; 5 ethyl 2' fluorouracil arabinoside; virus inhibition; viremia; recombinant beta interferon; adenoviridae infections; simiae; interferon type i, recombinant; human; priority journal; article; support, u.s. gov't, p.h.s.; cercopithecine herpesvirus 9; varicella virus; hu rifnβ; simian varicella virus; delta herpes virus; adenoviruses, simian
Journal Title:	Antiviral Research
Volume:	13
Issue:	4
ISSN:	0166-3542
Publisher:	Elsevier Science, Inc.
Date Published:	1990-04-01
Start Page:	165
End Page:	174
Language:	English
DOI:	10.1016/0166-3542(90)90035-6
PUBMED:	2166466
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025269583&doi=10.1016%2f0166-3542%2890%2990035-6&partnerID=40&md5=005a129bb7b9f0589ebebbe08c725d8a
Notes:	Article -- Source: Scopus

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