| Abstract: |
Ninety-eight patients with common varied immunodeficiency have been observed for periods of 1-13 years. In 1986, 78 were alive, 19 had died, and 1 could not be located. Eleven patients in the group had developed cancer; two patients had had two cancers. Of the total number of neoplastic malignancies, seven were non-Hodgkin's lymphoma, one patient had a Waldenstrom's macroglobulinemia, and nine of the patients who developed cancer were female. Cancer developed in the fifth or sixth decade of life for 10 of the 11 patients. These data show an 8- to 13-fold increase in cancer in general for patients who have this immunodeficiency and a 438-fold increase in lymphoma for females. © 1987 Plenum Publishing Corporation. |
| Keywords: |
child; aged; major clinical study; cancer incidence; neoplasms; time factors; risk; lymphoma; immune deficiency; neoplasms, multiple primary; immunity, cellular; patient; middle age; hypogammaglobulinemia; cancer; human; male; female; agammaglobulinemia; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; blood and hemopoietic system; common varied immunodeficiency
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