Author: | Markman, M. |
Article Title: | Intraperitoneal cisplatin chemotherapy |
Abstract: | The intraperitoneal delivery of cisplatin as treatment of tumors principally confined to the peritoneal cavity (such as ovarian carcinoma and mesothelioma) is based on sound pharmacological principles. Early phase clinical trials have confirmed both the pharmacokinetic advantage and the safety of this approach. Objective responses (including surgically defined complete remissions) have been observed in patients with refractory ovarian carcinoma who have failed systemically delivered cisplatin, confirming the potential superiority of this technique over standard methods of cisplatin administration. |
Keywords: | cancer chemotherapy; review; cisplatin; ovary carcinoma; mesothelioma; short survey; pharmacokinetics; intraperitoneal drug administration; human |
Journal Title: | ISI Atlas of Science: Pharmacology |
Volume: | 1 |
Issue: | 3 |
ISSN: | 0890-9083 |
Publisher: | Thomson Reuters |
Date Published: | 1987-01-01 |
Start Page: | 225 |
End Page: | 227 |
Language: | English |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |