Intraperitoneal therapy in the management of ovarian carcinoma Conference Paper


Authors: Markman, M.; Hakes, T.; Reichman, B.; Hoskins, W.; Rubin, S.; Jones, W.; Almadones, L.; Lewis, J. L. Jr
Title: Intraperitoneal therapy in the management of ovarian carcinoma
Conference Title: 7th Annual Ella T. Grasso Memorial Conference
Abstract: The intraperitoneal administration of chemotherapeutic and biological agents as therapy of ovarian carcinoma is based on both theoretical considerations and experimental evaluations which suggest that tumor present in the cavity can be exposed to higher concentrations of certain antineoplastic drugs than can be accomplished if the agents are administered systemically. Recent clinical data have confirmed both the safety and pharmacokinetic advantage associated with this approach. Surgically defined responses have been observed in patients with small-volume residual refractory ovarian carcinoma treated with several single-agent and combination intraperitoneal therapeutic programs. While significant activity has been noted in this clinical setting, a clearly defined role for intraperitoneal treatment in the standard management of ovarian carcinoma remains to be determined.
Keywords: cancer chemotherapy; review; cisplatin; doxorubicin; fluorouracil; antineoplastic agents; methotrexate; neurotoxicity; ovarian neoplasms; carboplatin; neoplasm recurrence, local; thrombocytopenia; antineoplastic combined chemotherapy protocols; melphalan; abdominal pain; mitoxantrone; ovary carcinoma; mitomycin c; infusions, parenteral; drug evaluation; intraperitoneal drug administration; human; female; article; support, non-u.s. gov't
Journal Title Yale Journal of Biology and Medicine
Volume: 62
Issue: 4
Conference Dates: 1989 Nov 15
Conference Location: New Haven, CT
ISBN: 0044-0086
Publisher: Yale Journal of Biology and Medicine, Inc.  
Date Published: 1989-07-01
Start Page: 393
End Page: 403
Language: English
PUBMED: 2688324
PROVIDER: scopus
PMCID: PMC2589079
DOI/URL:
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. William Hoskins
    239 Hoskins
  2. Lois Ann Cassidy
    72 Cassidy
  3. Thomas B Hakes
    77 Hakes
  4. Walter   Jones
    85 Jones
  5. John   Lewis
    98 Lewis
  6. Maurie Markman
    80 Markman
  7. Stephen C. Rubin
    94 Rubin