Hypothesis regarding the nature of the fragile X mutation: A reply to Winter and Pembrey Journal Article
| Authors: | Brown, W. T.; Sherman, S. L.; Dobkin, C. S. |
| Article Title: | Hypothesis regarding the nature of the fragile X mutation: A reply to Winter and Pembrey |
| Abstract: | Pembrey et al. (1985) proposed a hypothesis regarding the nature of the fragile X [fra(X)] mutation. Recently they analyzed DNA linkage data (Winter and Pembrey 1986) that we and others have published on fra(X) pedigrees, found significant linkage heterogeneity, and modified their hypothesis to explain the observations. We would like to point out that their modified hypothesis is not supported by the data available. © 1987 Springer-Verlag. |
| Keywords: | clinical article; mutation; heredity; editorial; central nervous system; dna; models, genetic; genetic linkage; etiology; fragile x syndrome; human; priority journal; sex chromosome aberrations; congenital disorder; premutation; x chromosome fragility |
| Journal Title: | Human Genetics |
| Volume: | 75 |
| Issue: | 3 |
| ISSN: | 0340-6717 |
| Publisher: | Springer |
| Date Published: | 1987-03-01 |
| Start Page: | 294 |
| End Page: | 295 |
| Language: | English |
| DOI: | 10.1007/bf00281078 |
| PUBMED: | 3557453 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
