Regulation of Thy-1 gene expression in transgenic mice Journal Article

  


Authors: Gordon, J. W.; Garin Chesa, P.; Nishimura, H.; Rettig, W. J.; Maccari, J. E.; Endo, T.; Seravalli, E.; Seki, T.; Silver, J.
Article Title: Regulation of Thy-1 gene expression in transgenic mice
Abstract: Genomic DNA fragments encompassing the human Thy-1 or mouse Thy-1.1 gene have been microinjected into pronuclei of mouse embryos homozygous for the Thy-1.2 allele. In the resulting transgenic mice, the human gene is expressed in a pattern characteristic of normal human tissues, and is not influenced by the pattern of endogenous mouse Thy-1 expression. The mouse Thy-1.1 gene fragment is expressed in a pattern typical of mouse Thy-1, although it is more limited in its distribution. The results indicate the presence of multiple cis-acting regulators of Thy-1 gene expression that have changed in both their character and arrangement over the course of Thy-1 gene evolution. © 1987.
Keywords: genetics; mouse; animal; mice; embryo; monoclonal antibody; gene expression regulation; membrane antigen; antibodies, monoclonal; cytochemistry; histocytochemistry; antigens, surface; microinjections; microinjection; thy 1 antigen; antigens, thy-1; dna, recombinant; recombinant dna; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; antigens, thy 1
Journal Title: Cell
Volume: 50
Issue: 3
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 1987-07-31
Start Page: 445
End Page: 452
Language: English
DOI: 10.1016/0092-8674(87)90498-3
PUBMED: 2886226
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023669099&doi=10.1016%2f0092-8674%2887%2990498-3&partnerID=40&md5=932443e6a3fcf3071491493d320fdc40
Notes: Article -- Export Date: 5 February 2021 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Pilar Garin-Chesa
    73 Garin-Chesa
  2. Wolfgang J. Rettig
    85 Rettig
Related MSK Work