Phase I trial of homoharringtonine in children with refractory leukemia Journal Article
| Authors: | Tan, C. T. C.; Luks, E.; Bacha, D. M.; Steinherz, P.; Steinherz, L.; Mondora, A. |
| Article Title: | Phase I trial of homoharringtonine in children with refractory leukemia |
| Abstract: | Continuous infusion of homoharringtonine was administered to 17 children with refractory leukemia. Ten children with acute lymphoblastic leukemia received a total of 18 courses and seven children with acute nonlymphoblastic leukemia had a total of 13 courses. Doses were escalated from 1.65 to 8.5 mg/m2 for 5-10 consecutive days. Side effects included mild nausea and vomiting and transient changes in liver enzymes. Mucositis and diarrhea were more frequently seen at higher dose levels. Grade 3 hypotension and pain were seen at doses of 7 mg/m2 for 10 days. This is considered to be the maximum tolerated dose in this limited phase I trial. None of these previously heavily treated patients achieved a marrow remission. |
| Keywords: | adolescent; child; preschool child; child, preschool; leukemia; infant; leukemia, myeloid; lymphatic leukemia; alkaloids; homoharringtonine; blast cell crisis; myeloid leukemia; blast crisis; alkaloid; leukemia, lymphocytic; harringtonines; humans; human; male; female; article; harringtonine derivative |
| Journal Title: | Cancer Treatment Reports |
| Volume: | 71 |
| Issue: | 12 |
| ISSN: | 0361-5960 |
| Publisher: | National Cancer Institute |
| Date Published: | 1987-12-01 |
| Start Page: | 1245 |
| End Page: | 1248 |
| Language: | English |
| PUBMED: | 3480043 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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