Pilot study of 5-azacytidine (5-AZA) and carboplatin (CBDCA) in patients with relapsed/refractory leukemia Journal Article

  


Authors: Kritz, A. D.; Raptis, G.; Menendez-Botet, C.; Maslak, P.; Jakubowski, A.
Article Title: Pilot study of 5-azacytidine (5-AZA) and carboplatin (CBDCA) in patients with relapsed/refractory leukemia
Abstract: 5-azacytidine (5-AZA) and carboplatin (CBDCA) are two agents which have demonstrated antileukemic activity in a number of phase I-II trials. Their mechanisms of action and pharmacology related to cell resistance suggested suitability for combination therapy. The aim of this pilot study was to evaluate the effects of this combination in the treatment of patients with relapsed/refractory acute leukemia. A total of 21 patients was enrolled. 5-azacytidine, at doses ranging from 50-150 mg/m2/day, was administered as a 2-hr infusion for 5 consecutive days. On day 3, patients began a 5-day course of CBDCA given as a 24-hr continuous intravenous infusion of 250 mg/m2/day. There were no complete remissions with this regimen. Although there were three partial responses, these were generally of short duration. Nonhematologic toxicities were mild. No correlation was seen between response and serum platinum levels. These results demonstrate that the 5-AZA/CBDCA combination is ineffective therapy for heavily pretreated patients with acute leukemia.
Keywords: adult; clinical article; aged; middle aged; leukemia; clinical trial; cancer recurrence; drug efficacy; carboplatin; gastrointestinal symptom; stomatitis; antineoplastic combined chemotherapy protocols; recurrence; acute leukemia; pilot projects; azacitidine; intravenous drug administration; 5-azacytidine; humans; human; male; female; priority journal; article
Journal Title: American Journal of Hematology
Volume: 51
Issue: 2
ISSN: 0361-8609
Publisher: John Wiley & Sons  
Date Published: 1996-02-01
Start Page: 117
End Page: 121
Language: English
DOI: 10.1002/(sici)1096-8652(199602)51:2<117::aid-ajh4>3.0.co;2-0
PUBMED: 8579051
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030064474&doi=10.1002%2f%28SICI%291096-8652%28199602%2951%3a2%3c117%3a%3aAID-AJH4%3e3.0.CO%3b2-0&partnerID=40&md5=bb4a3c1ce584eea36521b1df663bbb96
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. Ann Jakubowski
    455 Jakubowski
  2. Peter Maslak
    197 Maslak
  3. George Raptis
    29 Raptis
  4. Celia J Menendez-Botet
    25 Menendez-Botet
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