Reproductive history and risk of second primary breast cancer: The WECARE study Journal Article
| Authors: | Largent, J. A.; Capanu, M.; Bernstein, L.; Langholz, B.; Mellemkjaer, L.; Malone, K. E.; Begg, C. B.; Haile, R. W.; Lynch, C. F.; Anton-Culver, H.; Wolitzer, A.; Bernstein, J. L. |
| Article Title: | Reproductive history and risk of second primary breast cancer: The WECARE study |
| Abstract: | Background: Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results. Methods: We employed a case-control study nested within five population-based cancer registries in the United States and Denmark to examine associations between reproductive history and CBC risk. Cases were women with asynchronous CBC who had their first primary invasive breast cancer before age 55 years. Two controls, who had only one primary breast cancer diagnosis, were individually matched to each case on age and year of diagnosis, race, and registry. A total of 694 case-control triplets and 11 case-control pairs were enrolled. Information regarding possible CBC risk factors was obtained via telephone interviews. Multivariable conditional logistic regression was used to estimate rate ratios (RR) and 95% confidence intervals (95% CI) associated with risk factors of interest. Results: Increasing number of full-term pregnancies (FTP) was inversely associated with CBC risk (P trend, 0.001). Women who reported menarche before age 13 years had an increased risk of CBC (RR, 1.26; 95% CI, 1.01-1.58). Age at first FTP, breastfeeding history, and age at menopause were not significantly associated with CBC risk. Conclusions: These results suggest age at menarche and parity, which are established risk factors for first primary breast cancer, are associated with CBC, whereas other reproductive risk factors associated with first primary breast cancer, such as age at first FTP, are less important factors in the development of CBC. Copyright © 2007 American Association for Cancer Research. |
| Keywords: | adult; controlled study; aged; middle aged; major clinical study; case-control studies; anamnesis; cancer risk; united states; cohort studies; breast cancer; logistic models; risk factors; age factors; breast neoplasms; risk factor; menarche; questionnaires; registries; cancer registry; pregnancy; neoplasm invasiveness; neoplasms, second primary; second cancer; menopause; denmark; structured questionnaire; parity; reproductive history; interviews; breast feeding; primigravida; gravidity |
| Journal Title: | Cancer Epidemiology Biomarkers and Prevention |
| Volume: | 16 |
| Issue: | 5 |
| ISSN: | 1055-9965 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2007-05-01 |
| Start Page: | 906 |
| End Page: | 911 |
| Language: | English |
| DOI: | 10.1158/1055-9965.epi-06-1003 |
| PUBMED: | 17507614 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: CEBPE" - "Source: Scopus" |
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