Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line Journal Article
| Authors: | Zhao, Q.; Caballero, O. L.; Levy, S.; Stevenson, B. J.; Iseli, C.; de Souza, S. J.; Galante, P. A.; Busam, D.; Leversha, M. A.; Chadalavada, K.; Rogers, Y. H.; Venter, J. C.; Simpson, A. J. G.; Strausberg, R. L. |
| Article Title: | Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line |
| Abstract: | We have identified new genomic alterations in the breast cancer cell line HCC1954, using high-throughput transcriptome sequencing. With 120 Mb of cDNA sequences, we were able to identify genomic rearrangement events leading to fusions or truncations of genes including MRE11 and NSD1, genes already implicated in oncogenesis, and 7 rearrangements involving other additional genes. This approach demonstrates that high-throughput transcriptome sequencing is an effective strategy for the characterization of genomic rearrangements in cancers. © 2009 by The National Academy of Sciences of the USA. |
| Keywords: | unclassified drug; gene mutation; gene sequence; human cell; dna-binding proteins; mre11 protein; breast cancer; gene expression profiling; nuclear protein; neoplasm proteins; cell line, tumor; breast neoplasms; carcinogenesis; nuclear proteins; gene rearrangement; cancer cell; carrier proteins; base sequence; transcriptome; genome, human; complementary dna; dna, complementary; cancer genome; transcriptome sequencing; protein nsd1 |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 106 |
| Issue: | 6 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 2009-02-10 |
| Start Page: | 1886 |
| End Page: | 1891 |
| Language: | English |
| DOI: | 10.1073/pnas.0812945106 |
| PUBMED: | 19181860 |
| PROVIDER: | scopus |
| PMCID: | PMC2633215 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 21" - "Export Date: 30 November 2010" - "CODEN: PNASA" - "Source: Scopus" |
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