Recombinant human granulocyte-colony stimulating factor: In vitro and in vivo effects on myelopoiesis Journal Article
| Authors: | Welte, K.; Bonilla, M. A.; Gabrilove, J. L.; Gillio, A. P.; Potter, G. K.; Moore, M. A.; O'Reilly, R. J.; Boone, T. C.; Souza, L. M. |
| Article Title: | Recombinant human granulocyte-colony stimulating factor: In vitro and in vivo effects on myelopoiesis |
| Abstract: | The results presented in this paper demonstrate that recombinant human granulocyte-colony stimulating factor (rhG-CSF) is a potent myelopoetic growth and differentiation factor in vivo. RhG-CSF was able to shorten the time period of neutrophil recovery in both cyclophosphamide (CY)-induced myelosuppression and following bone marrow transplantation (BMT) in primates. Its ability to significantly shorten the period of chemotherapy-induced bone marrow hypoplasia may allow clinicians to increase the frequency or dosage of chemotherapeutic agents. In addition, the increase in absolute numbers of functionally active neutrophils may have a profound effect on the rate and severity of neutropenia-related sepsis. Furthermore, the activities reported here indicate a potential role for rhG-CSF in the treatment of patients with myelodysplastic syndrome, congential agranulocytosis, radiation-induced myelosuppression, and after bone marrow transplantation. |
| Keywords: | leukemia; neutropenia; nonhuman; animal cell; animals; mice; bone marrow cells; bone marrow; animal experiment; cyclophosphamide; cell differentiation; in vitro study; tumor cells, cultured; recombinant proteins; hematopoietic stem cells; hematopoiesis; neutrophils; bone marrow transplantation; transplantation, autologous; colony-stimulating factors; ape; macaca fascicularis; bone marrow diseases; colony stimulating factor; humans; priority journal; leukemia, experimental; hematopoiesis, extramedullary; blood and hemopoietic system |
| Journal Title: | Blood Cells |
| Volume: | 13 |
| Issue: | 1-2 |
| ISSN: | 0340-4684 |
| Publisher: | Springer Verlag |
| Date Published: | 1987-01-01 |
| Start Page: | 17 |
| End Page: | 26; discussion 26-30 |
| Language: | English |
| PUBMED: | 3311216 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
