Localization of radioiodinated monoclonal antibody in colorectal cancer: Initial dosimetry results Journal Article
| Authors: | Cohn, K. H.; Welt, S.; Banner, W. P.; Harrington, M.; Yeh, S.; Sakamoto, J.; Cardon-Cardo, C.; Daly, J.; Kemeny, N.; Cohen, A.; Lloyd, K.; Decosse, J.; Oettgen, H.; Old, L. |
| Article Title: | Localization of radioiodinated monoclonal antibody in colorectal cancer: Initial dosimetry results |
| Abstract: | HT-29-15 is an IgG1 monoclonal antibody reacting with a neuraminidase-sensitive determinant on a cell-surface antigen (molecular weight, 200 000 daltons) present on the colon cancer cell line HT-29. HT-29-15 was selected for a tumor localization study because the antigen was shown to be present, by immunohistochemical staining, in a high percentage of primary and metastatic colorectal cancers. HT-29-15 labeled with iodine 131 was given intravenously over a dose range of 0.2 to 10.0 mg to 23 patients with colorectal cancer. No significant toxicity was seen. Imaging of hepatic metastases was successful from days 5 to 7. Analysis of tissue radioactivity by biopsy showed that the tumor-liver ratio increased from day 1 to day 7, suggesting more rapid clearance of antibody from normal tissue than from tumor. Thus, tissue biopsy specimens and scintigraphy have shown that imaging of metastatic colorectal cancer is possible with monoclonal antibody HT-29-15. Tissue biopsy specimens are essential for demonstrating specificity of localization. Scans alone provide insufficient evidence of specific localization by monoclonal antibodies. Simultaneous infusion of a nonreactive control antibody would be necessary for specific localization to be demonstrated unequivocally. © 1987, American Medical Association. All rights reserved. |
| Keywords: | adult; clinical article; aged; liver neoplasms; comparative study; animal; mice; metastasis; colonic neoplasms; tumor antigen; biopsy; time factors; dose-response relationship, radiation; monoclonal antibody; liver; antibodies, monoclonal; immunoglobulin g; iodine radioisotopes; evaluation studies; rectal neoplasms; colon; human; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Archives of Surgery |
| Volume: | 122 |
| Issue: | 12 |
| ISSN: | 0004-0010 |
| Publisher: | American Medical Association |
| Date Published: | 1987-12-01 |
| Start Page: | 1425 |
| End Page: | 1429 |
| Language: | English |
| DOI: | 10.1001/archsurg.1987.01400240073013 |
| PUBMED: | 3689120 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus; Acknowledgements: We would like to thank Murray Brennan, MD, Daniel Coit, MD, and Man Shiu, MD, for referring patients for preoperative localization studies; Kathleen Weinstein, Mary Ellen McGroarty, and Beatrice Yin for performing antigen-typing studies; Elizabeth Carswell-Richards and her staff for HT-29-15 production; and Elsa Seguritan for radiolabeling the antibody. |
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