Local recurrence in adult soft-tissue sarcoma: A randomized trial of brachytherapy Journal Article

  


Authors: Brennan, M. F.; Hilaris, B.; Shiu, M. H.; Lane, J.; Magill, G.; Friedrich, C.; Hajdu, S. I.
Article Title: Local recurrence in adult soft-tissue sarcoma: A randomized trial of brachytherapy
Abstract: We conducted a prospective randomized study of the benefit of adjuvant radiation therapy delivered by the brachytherapy technique in 117 adult patients who had soft-tissue sarcoma that was on an extremity or superficially localized to the trunk. A significant decrease in local recurrence was demonstrated in the patients receiving brachytherapy. The benefit did not appear to be due to any maldistribution in the known prognostic factors of size, site, depth, presentation with recurrence, or histologic grade. The decrease in local recurrence appears to be due to the decreased local recurrence in high-grade sarcomas. Survival differences were not identified, and accrual and follow-up were continued. © 1987, American Medical Association. All rights reserved.
Keywords: adult; major clinical study; comparative study; methodology; prospective studies; neoplasm recurrence, local; sarcoma; tumor recurrence; soft tissue sarcoma; brachytherapy; iridium radioisotopes; clinical trials; soft tissue neoplasms; random allocation; middle age; human; male; female; support, non-u.s. gov't
Journal Title: Archives of Surgery
Volume: 122
Issue: 11
ISSN: 0004-0010
Publisher: American Medical Association  
Date Published: 1987-11-01
Start Page: 1289
End Page: 1293
Language: English
DOI: 10.1001/archsurg.1987.01400230075014
PUBMED: 3314794
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023610185&doi=10.1001%2farchsurg.1987.01400230075014&partnerID=40&md5=d2f0acbdd4f2a58ef43f4ee6550063e7
Notes: Article -- Export Date: 5 February 2021 -- Source: Scopus; Acknowledgements: Dr Brennan acknowledges the support of the attending staff and fellows of the Department of Surgery, who helped implement the trial, and the attending staff of the Department of Radiation Oncology, who administered the radiation therapy. Jeffrey Gaynor, PhD, provided statistical criticism. Gwen Besson provided graphic and secretarial support.
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Murray F Brennan
    1059 Brennan
  2. Gordon B. Magill
    30 Magill
  3. Joseph M. Lane
    66 Lane
  4. Basil B Hilaris
    43 Hilaris
  5. Steven I. Hajdu
    80 Hajdu
  6. Man-Hei Shiu
    44 Shiu
Related MSK Work