Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma Journal Article

Authors: Pisters, P. W.; Harrison, L. B.; Leung, D. H.; Woodruff, J. M.; Casper, E. S.; Brennan, M. F.
Article Title: Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma
Abstract: Purpose: This trial was performed to evaluate the impact of adjuvant brachytherapy on local and systemic recurrence rates in patients with soft tissue sarcoma. Patients and Methods: In a single-institution prospective randomized trial, 164 patients were randomized intraoperatively to receive either adjuvant brachytherapy (BRT) or no further therapy (no BRT) after complete resection of soft tissue sarcomas of the extremity or superficial trunk. The adjuvant radiation was administered by iridium-192 implant, which delivered 42 to 45 Gy over 4 to 6 days. The two study groups had comparable distributions of patient and tumor factors, including age, sex, tumor site, tumor size, and histologic type and grade. Results: With a median follow-up time of 76 months, the 5-year actuarial local control rates were 82% and 69% in the BRT and no BRT groups (P = .04), respectively. Patients with high- grade lesions had local control rates of 89% (BRT) and 66% (no BRT) (P = .0025). BRT had no impact on local control in patients with low-grade lesions(P = .49). The 5-year freedom-from-distant-recurrence rates were 83% and 76% in the BRT and no BRT groups (P = .60), respectively. Analysis by histologic grade did not demonstrate an impact of BRT an the development of distant metastasis, despite the improvement in local control noted in patients with high-grade lesions. The 5-year disease-specific survival rates for the BRT and no BRT groups were 84% and 81% (P = .65), respectively, with no impact of BRT regardless of tumor grade. Conclusion: Adjuvant brachytherapy improves local control after complete resection of soft tissue sarcomas. This improvement in local control is limited to patients with high- grade histopathology. The reduction in local recurrence in patients with high-grade lesions is not associated with a significant reduction in distant metastasis or improvement in disease-specific survival.
Keywords: adult; cancer survival; controlled study; human tissue; aged; disease-free survival; middle aged; human cell; major clinical study; clinical trial; histopathology; radiotherapy, adjuvant; recurrence risk; follow up; follow-up studies; cancer grading; prospective studies; metastasis; controlled clinical trial; neoplasm recurrence, local; randomized controlled trial; sarcoma; wound healing; soft tissue sarcoma; brachytherapy; regression analysis; humans; human; male; female; priority journal; article
Journal Title: Journal of Clinical Oncology
Volume: 14
Issue: 3
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 1996-03-01
Start Page: 859
End Page: 868
Language: English
PUBMED: 8622034
PROVIDER: scopus
DOI: 10.1200/JCO.1996.14.3.859
Notes: Article -- Export Date: 22 November 2017 -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    759 Brennan
  2. Denis Heng Yan Leung
    112 Leung
  3. Ephraim S Casper
    57 Casper
  4. James M Woodruff
    128 Woodruff