Non-Hodgkin's lymphomas: Characteristics of long-term survivors following conservative treatment Journal Article

  


Authors: Straus, D. J.; Gaynor, J. J.; Leiberman, P. H.; Filippa, D. A.; Koziner, B.; Clarkson, B. D.
Article Title: Non-Hodgkin's lymphomas: Characteristics of long-term survivors following conservative treatment
Abstract: A most important set of prognostic factors for survival among 467 patients with non-Hodgkin's lymphoma receiving conservative treatment was determined statistically by the Cox proportional hazards model. Non-Hodgkin's lymphoma was diagnosed in these patients between 1958 and 1969. Initial biopsy material was classified according to the Working Formulation, and the Rappaport, Kiel, and Lukes-Collins systems. The Cox analysis identified a group of 37 patients with a median survival of 150 months. These patients had the following characteristics: (1) small lymphocyte, plasmacytoid lymphocyte, small cleaved, large cleaved or non-cleaved follicular center cell histologic subtype (Lukes-Collins); (2) no bulky involvement of mesenteric nodes or critical organs-kidney, urinary tract, or pleura; (3) stages I to III disease (78 percent stage I or IE); (4) no B symptoms; (5) age below 60 years; (6) initial resection as a reflection of localized disease. Paients with advanced-stage non-Hodgkin's lymphoma receiving conservative treatment have a relatively short survival (median, less than five years) regardless of histologic subtype. © 1987.
Keywords: adolescent; adult; aged; retrospective studies; major clinical study; combined modality therapy; follow-up studies; lymph nodes; neoplasm staging; histology; nonhodgkin lymphoma; lymphoma, non-hodgkin; regression analysis; middle age; prognosis; human
Journal Title: The American Journal of Medicine
Volume: 82
Issue: 2
ISSN: 0002-9343
Publisher: Elsevier Inc.  
Date Published: 1987-02-01
Start Page: 247
End Page: 256
Language: English
DOI: 10.1016/0002-9343(87)90064-7
PUBMED: 3812517
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023634149&doi=10.1016%2f0002-9343%2887%2990064-7&partnerID=40&md5=b5e3dd7fe6f2a6279a2a80223d7a8292
Notes: Article -- Export Date: 5 February 2021 -- Source: Scopus
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MSK Authors
  1. Daniel A Filippa
    148 Filippa
  2. David J Straus
    356 Straus
  3. Bayard Clarkson
    220 Clarkson
  4. Jeffrey J. Gaynor
    36 Gaynor
  5. Benjamin Koziner
    52 Koziner
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