Interferon-α resistance associated genes in renal cell carcinoma identified by expression profiling Journal Article

  


Authors: Korkola, J. E.; Kondagunta, G. V.; Reuter, V. E.; Motzer, R. J.; Chaganti, R. S. K.
Article Title: Interferon-α resistance associated genes in renal cell carcinoma identified by expression profiling
Abstract: Purpose: We identified differentially expressed genes associated with response to pegylated interferon-α treatment in patients with renal cell carcinoma. Materials and Methods: We performed expression profiling on renal cell carcinoma specimens isolated from 23 patients with metastatic disease who were subsequently treated with interferon. Significance Analysis for Microarrays software was used to identify genes that were differentially expressed between patients with partial response compared to those with disease progression. Results: A candidate gene approach looking at VHL and known target genes did not identify any genes whose expression correlated with patient response. A global analysis of approximately 54,000 probe sets identified 4 genes that had expression correlated with response. Reverse transcriptase-polymerase chain reaction analysis of 2 of these genes confirmed that they were more highly expressed in tumors from patients who responded to interferon-α. Interestingly, both of these genes mapped to 4q31-32, a region that has been implicated as the site of a potential tumor suppressor gene in renal cell carcinoma. Conclusions: We have identified 4 genes (3 uncharacterized and 1 known) that may prove useful in predicting response to interferon-α treatment in patients with renal cell carcinoma. © 2007 American Urological Association.
Keywords: clinical article; controlled study; human tissue; treatment response; human cell; gene; peginterferon alpha2b; reverse transcription polymerase chain reaction; genes; gene expression profiling; genetic association; drug resistance, neoplasm; kidney carcinoma; kidney neoplasms; gene mapping; tumor suppressor gene; carcinoma, renal cell; carcinoma; dna microarray; pharmacogenetics; tumor suppressor; vhl gene; von hippel lindau protein; chromosome 4q; interferon-alpha; renal cell; gene isolation; abcd3 gene; hs 11325 gene; hs 76704 gene; hs 94122 gene
Journal Title: Journal of Urology
Volume: 177
Issue: 4
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 2007-04-01
Start Page: 1264
End Page: 1268
Language: English
DOI: 10.1016/j.juro.2006.11.087
PUBMED: 17382702
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33947217842&partnerID=40&md5=4c388f658d774ab2de1f5dbfb744a67f
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: JOURA" - "Source: Scopus"
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MSK Authors
  1. Gnanamba Kondagunta
    46 Kondagunta
  2. Robert Motzer
    1246 Motzer
  3. James E Korkola
    24 Korkola
  4. Victor Reuter
    1228 Reuter
  5. Raju S K Chaganti
    391 Chaganti
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