PET for staging in rhabdomyosarcoma: An evaluation of PET as an adjunct to current staging tools Journal Article
| Authors: | Klem, M. L.; Grewal, R. K.; Wexler, L. H.; Schoder, H.; Meyers, P. A.; Wolden, S. L. |
| Article Title: | PET for staging in rhabdomyosarcoma: An evaluation of PET as an adjunct to current staging tools |
| Abstract: | BACKGROUND: Complete staging of rhabdomyosarcoma is critical to deliver appropriate therapy. We evaluated the role of F-fluorodeoxyglucose positron emission tomography (PET) in the staging of patients with rhabdomyosarcoma. METHODS: Twenty-four patients with rhabdomyosarcoma had a PET scan during staging evaluation, before or within 13 days of initiation of therapy. PET was compared with computed tomography (CT), magnetic resonance imaging (MRI), bone scan, and pathology. RESULTS: Ninety-six sites were evaluated. All patients had positive PET scans at the primary site. Thirty-one PET positive sites at primary, regional, or distant sites were biopsied. Pathology in all 31 confirmed disease. Standardized uptake value for the primary site at diagnosis ranged from 2.4 to 12.7 (mean 6.4). At 23 sites, CT or MRI was equivocal for the detection of regional or distant spread. In these cases, a negative PET helped to exclude disease in 21 of 23 patients. PET failed to capture sites of disease visualized by CT, MRI, or bone scan at 10 sites. When comparing PET with the final clinical determination of disease extent, PET was 77% sensitive and 95% specific. CONCLUSIONS: These preliminary data indicate that PET is a useful adjunct in staging rhabdomyosarcoma. A prospective study of PET for staging of rhabdomyosarcoma is warranted. © 2007 Lippincott Williams & Wilkins, Inc. |
| Keywords: | adolescent; adult; child; clinical article; controlled study; child, preschool; middle aged; retrospective studies; cancer localization; conference paper; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; magnetic resonance imaging; staging; cancer diagnosis; neoplasm staging; sensitivity and specificity; radiopharmaceuticals; metastasis; computer assisted tomography; tomography, x-ray computed; tumor biopsy; infant; fluorodeoxyglucose f18; positron-emission tomography; predictive value of tests; intermethod comparison; rhabdomyosarcoma; evaluation studies; pet; bone scintiscanning |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 29 |
| Issue: | 1 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2007-01-01 |
| Start Page: | 9 |
| End Page: | 14 |
| Language: | English |
| DOI: | 10.1097/MPH.0b013e3180307693 |
| PUBMED: | 17230060 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 23" - "Export Date: 17 November 2011" - "CODEN: JPHOF" - "Source: Scopus" |
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