Breast conservation and axillary management after primary systemic therapy in patients with early-stage breast cancer: The Lucerne toolbox Review

  

Authors:	Dubsky, P.; Pinker, K.; Cardoso, F.; Montagna, G.; Ritter, M.; Denkert, C.; Rubio, I. T.; de Azambuja, E.; Curigliano, G.; Gentilini, O.; Gnant, M.; Günthert, A.; Hauser, N.; Heil, J.; Knauer, M.; Knotek-Roggenbauerc, M.; Knox, S.; Kovacs, T.; Kuerer, H. M.; Loibl, S.; Mannhart, M.; Meattini, I.; Penault-Llorca, F.; Radosevic-Robin, N.; Sager, P.; Španić, T.; Steyerova, P.; Tausch, C.; Vrancken Peeters, M. J. T. F. D.; Weber, W. P.; Cardoso, M. J.; Poortmans, P.
Review Title:	Breast conservation and axillary management after primary systemic therapy in patients with early-stage breast cancer: The Lucerne toolbox
Abstract:	Primary systemic therapy is increasingly used in the treatment of patients with early-stage breast cancer, but few guidelines specifically address optimal locoregional therapies. Therefore, we established an international consortium to discuss clinical evidence and to provide expert advice on technical management of patients with early-stage breast cancer. The steering committee prepared six working packages to address all major clinical questions from diagnosis to surgery. During a consensus meeting that included members from European scientific oncology societies, clinical trial groups, and patient advocates, statements were discussed and voted on. A consensus was reached in 42% of statements, a majority in 38%, and no decision in 21%. Based on these findings, the panel developed clinical guidance recommendations and a toolbox to overcome many clinical and technical requirements associated with the diagnosis, response assessment, surgical planning, and surgery of patients with early-stage breast cancer. This guidance could convince clinicians and patients of the major clinical advancements purported by primary systemic therapy, the use of less extensive and more targeted surgery to improve the lives of patients with breast cancer. © 2021 Elsevier Ltd
Keywords:	cancer chemotherapy; treatment response; review; systemic therapy; treatment planning; cancer staging; nuclear magnetic resonance imaging; lymph node dissection; clinical practice; breast cancer; tumor volume; evidence based practice; patient care; mammography; breast carcinoma; partial mastectomy; consensus development; clinician; patient advocacy; human; priority journal; multidisciplinary team; breast radiotherapy
Journal Title:	Lancet Oncology
Volume:	22
Issue:	1
ISSN:	1470-2045
Publisher:	Elsevier Science, Inc.
Date Published:	2021-01-01
Start Page:	e18
End Page:	e28
Language:	English
DOI:	10.1016/s1470-2045(20)30580-5
PUBMED:	33387500
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098485045&doi=10.1016%2fS1470-2045%2820%2930580-5&partnerID=40&md5=ca188c1537d659d32ca6fc2eb1e77dd2
Notes:	Review -- Export Date: 1 February 2021 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/176110