A high degree of HLA disparity arises from limited allelic diversity: Analysis of 1775 unrelated bone marrow transplant donor-recipient pairs Journal Article
| Authors: | Hurley, C. K.; Fernandez Vina, M.; Hildebrand, W. H.; Noreen, H. J.; Trachtenberg, E.; Williams, T. M.; Baxter-Lowe, L. A.; Begovich, A. B.; Petersdorf, E.; Selvakumar, A.; Stastny, P.; Hegland, J.; Hartzman, R. J.; Carston, M.; Gandham, S.; Kollman, C.; Nelson, G.; Spellman, S.; Setterholm, M. |
| Article Title: | A high degree of HLA disparity arises from limited allelic diversity: Analysis of 1775 unrelated bone marrow transplant donor-recipient pairs |
| Abstract: | The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analysis included the class I (A, B, C) and II (DRB1, DQA1, DQB1, DPA1, DPB1) loci. Most (>66%) of the predominantly Caucasian study population carried one or two of five to seven common alleles at each HLA locus. In spite of this limited diversity, 29% of the six of six antigen-matched transplants carried allele mismatches at HLA-A, -B, and/or -DRB1, and 92% carried at least one allele mismatch at one of the eight HLA loci tested. Of the 968 HLA-A,-B,-DRB1 allele-matched pairs, 89% carried mismatches at other HLA loci, predominantly at DP loci. The substantially greater than expected HLA allelic disparity between donor and recipient suggests extensive haplotypic diversity and underscores the importance of enhancing approaches to mitigate the deleterious effect of HLA mismatches. © 2007 American Society for Histocompatibility and Immunogenetics. |
| Keywords: | retrospective studies; human cell; gene locus; genetic variability; alleles; gene frequency; haplotype; hla matching; donor; tissue donors; hla dr antigen; histocompatibility antigens class i; hla a antigen; hla b antigen; bone marrow transplantation; hla-d antigens; hla antigen; hla antigens; african american; caucasian; hispanic; hla; histocompatibility testing; hla dp antigen; variation (genetics); hla dqb1 antigen; hla dqa1 antigen; allelism |
| Journal Title: | Human Immunology |
| Volume: | 68 |
| Issue: | 1 |
| ISSN: | 0198-8859 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2007-01-01 |
| Start Page: | 30 |
| End Page: | 40 |
| Language: | English |
| DOI: | 10.1016/j.humimm.2006.09.004 |
| PUBMED: | 17207710 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 23" - "Export Date: 17 November 2011" - "CODEN: HUIMD" - "Source: Scopus" |
