Recurrent laryngeal cancer presenting as delayed hypoparathyroidism Journal Article
| Authors: | Hsu, A. K.; Tabaee, A.; Kraus, D. H. |
| Article Title: | Recurrent laryngeal cancer presenting as delayed hypoparathyroidism |
| Abstract: | Background. Endocrine dysfunction following therapy for head and neck cancer has been previously described. Permanent hypoparathyroidism may result from the tumor, surgery, or radiation therapy. However, the incidence and significance of delayed hypoparathyroidism following treatment for laryngeal cancer remains unclear. Methods and Results. We report a patient who had stable serum calcium measurements on serial testing following concurrent chemoradiation and salvage laryngectomy for locally advanced laryngeal cancer. The patient subsequently presented 32 months following salvage laryngectomy with new onset, symptomatic hypocalcemia secondary to hypoparathyroidism. Subsequent evaluation revealed local recurrence. Conclusion. To our knowledge, this case represents the first report of delayed hypoparathyroidism as the presenting manifestation of recurrence following treatment for laryngeal cancer. Possible pathophysiologic mechanisms are discussed. ©2007 Wiley Periodicals, Inc. |
| Keywords: | adult; cancer chemotherapy; middle aged; cancer surgery; clinical feature; cancer recurrence; case report; laryngectomy; neck dissection; salvage therapy; carcinoma, squamous cell; laryngeal neoplasms; advanced cancer; pathophysiology; cancer radiotherapy; combined modality therapy; recurrent cancer; cancer incidence; neoplasm recurrence, local; calcium blood level; time factors; fatal outcome; larynx cancer; hypocalcemia; hypoparathyroidism; parathyroid |
| Journal Title: | Head & Neck |
| Volume: | 29 |
| Issue: | 9 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2007-09-01 |
| Start Page: | 889 |
| End Page: | 891 |
| Language: | English |
| DOI: | 10.1002/hed.20603 |
| PUBMED: | 17450540 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: HEANE" - "Source: Scopus" |
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