Tracking normalization of brain tumor vasculature by magnetic imaging and proangiogenic biomarkers Journal Article
| Authors: | Hormigo, A.; Gutin, P. H.; Rafii, S. |
| Article Title: | Tracking normalization of brain tumor vasculature by magnetic imaging and proangiogenic biomarkers |
| Abstract: | Clinical assessment of the response to antiangiogenic therapy has been cumbersome. A study in this issue of Cancer Cell demonstrates that a combination of magnetic resonance imaging (MRI) for quantification of normalized vessels with measurements of circulating levels of proangiogenic factors, including FGF2, SDF1, and viable circulating endothelial cells, provides an effective means to evaluate the response of recurrent glioblastoma to a prototypical pan-VEGF receptor tyrosine kinase inhibitor, AZD2171. © 2007 Elsevier Inc. All rights reserved. |
| Keywords: | treatment outcome; clinical trial; bevacizumab; drug dose reduction; drug withdrawal; nonhuman; antineoplastic agents; neuroimaging; nuclear magnetic resonance imaging; brain tumor; brain neoplasms; magnetic resonance imaging; biological marker; mouse; animals; platelet derived growth factor alpha receptor; enzyme inhibition; phase 2 clinical trial; breast cancer; tumor markers, biological; animal experiment; animal model; angiogenesis; neovascularization, pathologic; protein tyrosine kinase inhibitor; endothelium cell; fibroblast growth factor 2; glioblastoma; vasculotropin a; short survey; tumor model; methylated dna protein cysteine methyltransferase; corticosteroid; quinazolines; angiogenesis inhibitors; brain edema; platelet derived growth factor beta receptor; blood level; stromal cell derived factor 1; neutralizing antibody; blood vessel permeability; 4 (4 fluoro 2 methyl 5 indolyloxy) 6 methoxy 7 [3 (1 pyrrolidinyl)propoxy]quinazoline |
| Journal Title: | Cancer Cell |
| Volume: | 11 |
| Issue: | 1 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2007-01-01 |
| Start Page: | 6 |
| End Page: | 8 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2006.12.008 |
| PUBMED: | 17222788 |
| PROVIDER: | scopus |
| PMCID: | PMC2952447 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 17" - "Export Date: 17 November 2011" - "CODEN: CCAEC" - "Source: Scopus" |
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