Molecular diagnostics in central nervous system infections Journal Article
| Authors: | Nawar, T.; Kaltsas, A.; Tang, Y. W. |
| Article Title: | Molecular diagnostics in central nervous system infections |
| Abstract: | Central nervous system (CNS) infections can be life threatening if not diagnosed and treated early. The myriad clinical presentations of CNS infections can make a prompt diagnosis challenging. Multiple diagnostic modalities have been used in the past, including conventional microscopic examination, gram stain and cultures, antigen detection and serology, but these techniques have had major limitations - most notably in the diagnosis of viruses and other difficult to culture organisms. Advances in molecular diagnostics have largely replaced conventional techniques with a faster turnaround time and higher sensitivity and specificity. In this review we aim to summarize the currently available armamentarium of molecular assays, as well as their applications and limitations in diagnosing central nervous system infections. © 2021, Springer Nature Switzerland AG. |
| Keywords: | antigen detection; serology; specificity; sensitivity; culture; microscopic examination; central nervous system infections; gram stain; molecular methods; diagnostic modalities |
| Journal Title: | Current Clinical Neurology |
| ISSN: | 1559-0585 |
| Publisher: | Humana Press Inc |
| Date Published: | 2021-01-01 |
| Start Page: | 13 |
| End Page: | 36 |
| Language: | English |
| DOI: | 10.1007/978-3-030-56084-3_2 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter 2 in Hasbun R, Bloch KC, Bhimraj A, eds. "Neurological Complications of Infectious Diseases" (ISBN: 978-3-030-56083-6) -- Export Date: 4 January 2021 -- Source: Scopus |
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