Symptomatic chiari type I malformation after radiation therapy in an infant: Case report Journal Article
| Authors: | Hoffman, C. E.; Lis, E.; Wolden, S. L.; Souweidane, M. M. |
| Article Title: | Symptomatic chiari type I malformation after radiation therapy in an infant: Case report |
| Abstract: | OBJECTIVE: One previous case report has described the development of a Chiari I malformation in a child after fractionated radiation therapy to the anterior cranial base. The authors present an additional case of a 17-month-old girl treated for an isolated, malignant, rhabdoid tumor of the right neck with neoadjuvant chemotherapy, surgical exploration, and radiation therapy. CLINICAL PRESENTATION: The patient developed a Chiari I malformation and cervical syringomyelia 1.5 years after the treatment. The patient experienced two episodes of unresponsiveness before diagnosis, and the malformation was then identified on magnetic resonance imaging scans. INTERVENTION: Suboccipital decompressive craniectomy, and C1 laminectomy with autologous duraplasty were performed. RESULTS: Postoperative magnetic resonance imaging scans revealed reconstitution of cerebrospinal fluid at the foramen magnum and ascent of the cerebellar tonsils. The patient remains asymptomatic 5.5 years after treatment. CONCLUSION: The importance of this association is discussed in the context of the increasing use of radiation therapy in young children and infants. Copyright © by the Congress of Neurological Surgeons. |
| Keywords: | school child; treatment outcome; cancer surgery; case report; postoperative period; doxorubicin; cancer adjuvant therapy; cancer radiotherapy; topotecan; nuclear magnetic resonance imaging; cerebellum; multiple cycle treatment; etoposide; radiotherapy; cyclophosphamide; vincristine; radiation injury; ifosfamide; cerebrospinal fluid; infant; decompression surgery; decompression, surgical; radiation injuries; radiation therapy; craniotomy; rhabdomyosarcoma; brain hernia; rhabdoid tumor; laminectomy; cervical vertebrae; cervical spine; neck tumor; cerebellar diseases; foramen magnum; chiari malformation; cranial maturation; skull maturation; syringomyelia; chiari i malformation; craniectomy; internal carotid artery; arnold chiari malformation; cerebellum disease; arnold-chiari malformation |
| Journal Title: | Neurosurgery |
| Volume: | 60 |
| Issue: | 4 |
| ISSN: | 0148-396X |
| Publisher: | Wolters Kluwer |
| Date Published: | 2007-04-01 |
| Start Page: | E782 |
| Language: | English |
| DOI: | 10.1227/01.neu.0000255357.09819.58 |
| PUBMED: | 17415188 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "CODEN: NRSRD" - "Source: Scopus" |
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219Souweidane
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