Computed tomographic screening for lung cancer: Individualising the benefit of the screening Journal Article
| Authors: | Henschke, C. I.; Yankelevitz, D. F.; McCauley, D. I.; Sone, S.; Hanaoka, T.; Markowitz, S.; Miller, A.; Klingler, K.; Scherer, T.; Inderbitzi, R.; Zulueta, J.; Montuenga, L.; Bastarrika, G.; Giunta, S.; Crecco, M.; Pugliese, P.; Tockman, M.; Shaham, D.; Rice, K.; Aye, R.; Roberts, H.; Patsios, D.; Bauer, T.; Lally, J.; Austin, J. H. M.; Pearson, G. D. N.; Naidich, D.; McGuinness, G.; Rifkin, M.; Fiore, E.; Kopel, S.; Klippenstein, D.; Litwin, A.; Loud, P. A.; Kohman, L. J.; Scalzetti, E. M.; Khan, A.; Shah, R.; Smith, M. V.; Williams, H. T.; Lovett, L.; Mendelson, D. S.; Thurer, R.; Heelan, R. T.; Ginsberg, M. S.; Sullivan, F.; Ottinger, M.; Vafai, D.; Matalon, T. A. S.; Odzer, S. L.; Liu, X.; Sheppard, B.; Cole, E.; Wiernik, P. H.; Ray, D.; Pass, H.; Endress, C.; Mullen, D.; Kalafer, M.; Grannis, F.; Rotter, A.; Thorsen, M. K.; Hansen, R.; Camacho, E.; Luedke, D. |
| Article Title: | Computed tomographic screening for lung cancer: Individualising the benefit of the screening |
| Abstract: | Individuals concerned about their risk of lung cancer are recommended to talk with their physicians about computed tomographic screening for lung cancer. To provide the necessary information, the survival benefit of the screening, specific to a particular person for a particular round of screening, is needed. The probability of survival gain from the first, baseline, round of screening was addressed as the product of: 1) the screening resulting in a diagnosis of lung cancer; 2) not dying from some other cause for a sufficiently long period of time; and 3) cure resulting from pre-symptomatic treatment of lung cancer. These probabilities were estimated using the International Early Lung Cancer Action Program data on individuals aged 40-85 yrs with a cigarette smoking history of 0-150 pack-yrs. The estimated probability of survival gain ranged from 0.4% for a 60-yr-old with a 10-pack-yr smoking history who quit smoking 20 yrs ago, to 3.1% for a 70-yr-old current smoker with a 100 pack-yr history and 2.0% for an 85-yr-old current smoker with a 150-pack-yr history. When seeking counsel about initiation of screening for lung cancer, an estimate of the probability of survival gain from the first round of computed tomographic screening, specific to the person's age and history of smoking, can be provided. Copyright©ERS Journals Ltd 2007. |
| Keywords: | survival; adult; controlled study; aged; aged, 80 and over; middle aged; survival analysis; survival rate; major clinical study; cancer risk; united states; computer assisted tomography; lung neoplasms; risk factors; cancer screening; lung cancer; mass screening; smoking; tomography, x-ray computed; health program; probability; chi-square distribution; logistic regression analysis; international early lung cancer action program |
| Journal Title: | European Respiratory Journal |
| Volume: | 30 |
| Issue: | 5 |
| ISSN: | 0903-1936 |
| Publisher: | European Respiratory Society |
| Date Published: | 2007-11-01 |
| Start Page: | 843 |
| End Page: | 847 |
| Language: | English |
| DOI: | 10.1183/09031936.00000607 |
| PUBMED: | 17652316 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 17 November 2011" - "CODEN: ERJOE" - "Source: Scopus" |
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