Novel translational strategies in colorectal cancer research Journal Article
| Author: | Gil-Bazo, I. |
| Article Title: | Novel translational strategies in colorectal cancer research |
| Abstract: | Defining translational research is still a complex task. In oncology, translational research implies using our basic knowledge learnt from in vitro and in vivo experiments to directly improve diagnostic tools and therapeutic approaches in cancer patients. Moreover, the better understanding of human cancer and its use to design more reliable tumor models and more accurate experimental systems also has to be considered a good example of translational research. The identification and characterization of new molecular markers and the discovery of novel targeted therapies are two main goals in colorectal cancer translational research. However, the straightforward translation of basic research findings, specifically into colorectal cancer treatment and vice versa is still underway. In the present paper, a summarized view of some of the new available approaches on colorectal cancer translational research is provided. Pros and cons are discussed for every approach exposed. © 2007 WJG. All rights reserved. |
| Keywords: | cancer chemotherapy; gene mutation; clinical trial; nonhuman; antineoplastic agents; colorectal cancer; mass spectrometry; biological marker; gene targeting; melanoma; biomedical research; microrna; tumor markers, biological; small interfering rna; in vivo study; in vitro study; proteomics; cancer research; prostate cancer; colorectal neoplasms; hematologic malignancy; dna, neoplasm; genomics; drug bioavailability; dna microarray; matrix assisted laser desorption ionization time of flight mass spectrometry; liquid chromatography; protein microarray; two dimensional gel electrophoresis; translational research; targeted therapies; antisense oligonucleotide |
| Journal Title: | World Journal of Gastroenterology |
| Volume: | 13 |
| Issue: | 44 |
| ISSN: | 1007-9327 |
| Publisher: | Baishideng Publishing Group Inc |
| Date Published: | 2007-11-28 |
| Start Page: | 5902 |
| End Page: | 5910 |
| Language: | English |
| PUBMED: | 17990355 |
| PROVIDER: | scopus |
| PMCID: | PMC4205436 |
| DOI: | 10.3748/wjg.v13.i44.5902 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: WJGAF" - "Source: Scopus" |
