Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: Advancing basic and translational research and cooperation in DIPG Journal Article
| Authors: | Bartels, U.; Hawkins, C.; Vezina, G.; Kun, L.; Souweidane, M.; Bouffet, E. |
| Article Title: | Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank: Advancing basic and translational research and cooperation in DIPG |
| Abstract: | Diffuse intrinsic pontine glioma (DIPG) nearly exclusively affects children. The prognosis of DIPGs has remained grim despite more than three decades of clinical research and numerous clinical trials. More than 90% of the children with DIPG will succumb within 2 years of diagnosis. The tumor's incidence is still undefined, but data suggest 100-150 affected children annually in the US. The single proven effective treatment modality in DIPG remains radiation therapy. For the majority of patients however this treatment is only of transient effectiveness. Recent breakthroughs in the understanding of the molecular biology of DIPG have raised new hope and opened new avenues for therapeutic options. The advancement of basic and translational research and cooperation was the objective of the Toronto Think Tank, as new approaches are urgently needed. © Springer Science+Business Media, LLC. 2011. |
| Keywords: | cancer chemotherapy; cancer survival; protein expression; unclassified drug; intensity modulated radiation therapy; dose response; multimodality cancer therapy; nonhuman; risk benefit analysis; conference paper; cancer radiotherapy; temozolomide; cancer incidence; cancer immunotherapy; low drug dose; etoposide; interleukin 13; tumor biopsy; diagnostic imaging; platelet derived growth factor receptor; cancer research; clinical effectiveness; cancer control; gadolinium pentetate; chemoradiotherapy; translational research; pseudomonas exotoxin; receptor upregulation; immunotoxin; diffuse intrinsic pontine glioma; dipg; think tank; immunotoxin d2c7; trofosfamide; pontine glioma |
| Journal Title: | Journal of Neuro-Oncology |
| Volume: | 105 |
| Issue: | 1 |
| ISSN: | 0167-594X |
| Publisher: | Springer |
| Date Published: | 2011-01-01 |
| Start Page: | 119 |
| End Page: | 125 |
| Language: | English |
| DOI: | 10.1007/s11060-011-0704-4 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 January 2012" - "CODEN: JNODD" - "Source: Scopus" |
