Genome-wide association study identifies novel single nucleotide polymorphisms having age-specific effect on prostate-specific antigen levels Journal Article

   

Authors:	Li, W.; Bicak, M.; Sjoberg, D. D.; Vertosick, E.; Dahlin, A.; Melander, O.; Ulmert, D.; Lilja, H.; Klein, R. J.
Article Title:	Genome-wide association study identifies novel single nucleotide polymorphisms having age-specific effect on prostate-specific antigen levels
Abstract:	Background: Testing for prostate-specific antigen (PSA) levels in blood are widely used and associated with prostate cancer risk and outcome. After puberty, PSA levels increase by age and multiple single nucleotide polymorphisms (SNPs) have been found to be associated with PSA levels. However, the relationship between the effects of SNPs and age on PSA remains unknown. Methods: To test for SNP × age interaction, we conducted a genome-wide association study using 2394 men without prostate cancer diagnosis from Malmö, Sweden as a discovery set and 2137 men from the eMERGE study (USA) for validation. Linear regression was used to identify significant interactions between SNP and age (p < 1 × 10−4 for discovery, p <.05 for validation). Results: The 15 SNPs from three different loci (8p11.22, 8p12, 3q25.31) are found to have age-specific effect on PSA levels. Expression quantitative trait loci (eQTLs) analysis shows that 12 SNPs from 3q25.31 locus affect the expression level of three genes: KCNAB1, SLC33A1, PLCH1. Conclusions: Our results suggest that SNPs may have age-specific effect on PSA levels, which provides new direction to study genetic markers for PSA. © 2020 Wiley Periodicals LLC
Keywords:	prostate cancer; psa; snps; gwas; eqtl
Journal Title:	Prostate
Volume:	80
Issue:	16
ISSN:	0270-4137
Publisher:	John Wiley & Sons
Date Published:	2020-12-01
Start Page:	1405
End Page:	1412
Language:	English
DOI:	10.1002/pros.24070
PUBMED:	32914890
PROVIDER:	scopus
PMCID:	PMC7606728
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091377478&doi=10.1002%2fpros.24070&partnerID=40&md5=cde2bc3d35b03b91e8fc2916da540d96
Notes:	Article -- Export Date: 1 December 2020 -- Source: Scopus

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