Clinical research with advanced diffusion encoding methods in MRI Journal Article
| Authors: | Reymbaut, A.; Zheng, Y.; Li, S.; Sun, W.; Xu, H.; Daimiel Naranjo, I.; Thakur, S.; Pinker-Domenig, K.; Rajan, S.; Vanugopal, V. K.; Mahajan, V.; Mahajan, H.; Critchley, J.; Durighel, G.; Sughrue, M.; Bryskhe, K.; Topgaard, D. |
| Article Title: | Clinical research with advanced diffusion encoding methods in MRI |
| Abstract: | This chapter offers a comprehensive summary of applications of advanced diffusion encoding methods in MRI within a narrowly defined area of in vivo human measurements with imaging read-out and voxel-by-voxel data analysis. The list of methods comprises tensor-valued encoding to investigate cell densities, shapes, and orientations in heterogeneous tissues, time/frequency-dependent encoding for estimating structural length scales, adjustable velocity-encoding to monitor flow in the microcapillary network, double encoding with varying mixing times to assess diffusional exchange between distinct tissue microenvironments and across cell membranes, and relaxation-diffusion correlation to resolve and separately characterize tissue microenvironments in terms of their local chemical composition and microstructure. The shown examples include proof-of-concept measurements on healthy volunteers, pilot investigations of pathologies, and clinical research involving 10-100 subjects. Studied organs include brain, breast, prostate, liver, kidney, placenta, muscle, and peripheral nerve, with examples of pathologies from tumors, schizophrenia, multiple sclerosis, stroke, neurocysticercosis, pre-eclampsia, and chronic exertional compartment syndrome. © 2020 The Royal Society of Chemistry. |
| Keywords: | magnetic resonance imaging; cytology; diffusion; pathology; nuclear magnetic resonance spectroscopy; clinical research; peripheral nerves; multiple sclerosis; tissue; cells; encoding (symbols); compartment syndromes; chemical compositions; healthy volunteers; signal encoding; heterogeneous tissues; human measurements; micro-capillaries |
| Journal Title: | New Developments in NMR |
| Volume: | 24 |
| ISSN: | 2044-253X |
| Publisher: | Royal Society of Chemistry |
| Date Published: | 2020-01-01 |
| Start Page: | 406 |
| End Page: | 429 |
| Language: | English |
| DOI: | 10.1039/9781788019910-00406 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Chapter 14 in "Advanced Diffusion Decoding Methods in MRI" (ISBN: 978-1-78801-726-8) -- Export Date: 1 December 2020 -- Source: Scopus |
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