Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity Journal Article
| Authors: | Cyrta, J.; Augspach, A.; De Filippo, M. R.; Prandi, D.; Thienger, P.; Benelli, M.; Cooley, V.; Bareja, R.; Wilkes, D.; Chae, S. S.; Cavaliere, P.; Dephoure, N.; Uldry, A. C.; Lagache, S. B.; Roma, L.; Cohen, S.; Jaquet, M.; Brandt, L. P.; Alshalalfa, M.; Puca, L.; Sboner, A.; Feng, F.; Wang, S.; Beltran, H.; Lotan, T.; Spahn, M.; Kruithof-de Julio, M.; Chen, Y.; Ballman, K. V.; Demichelis, F.; Piscuoglio, S.; Rubin, M. A. |
| Article Title: | Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity |
| Abstract: | Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10–20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Using large patient datasets, patient-derived organoids and cancer cell lines, we identify mSWI/SNF subunits that are deregulated in NEPC and demonstrate that SMARCA4 (BRG1) overexpression is associated with aggressive disease. We also show that SWI/SNF complexes interact with different lineage-specific factors in NEPC compared to prostate adenocarcinoma. These data point to a role for mSWI/SNF complexes in therapy-related lineage plasticity, which may also be relevant for other solid tumors. © 2020, The Author(s). |
| Keywords: | mammalia; disease treatment; cell; plasticity; chemical composition; cancer |
| Journal Title: | Nature Communications |
| Volume: | 11 |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2020-11-03 |
| Start Page: | 5549 |
| Language: | English |
| DOI: | 10.1038/s41467-020-19328-1 |
| PUBMED: | 33144576 |
| PROVIDER: | scopus |
| PMCID: | PMC7642293 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2020 -- Source: Scopus |
