A liquid biopsy approach to early detection of bone marrow fibrosis via single-cell functional proteomics Conference Paper
| Authors: | Kim, D.; Chen, J.; Chen, Z.; Kleppe, M.; Levine, R. L.; Fan, R. |
| Title: | A liquid biopsy approach to early detection of bone marrow fibrosis via single-cell functional proteomics |
| Conference Title: | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Abstract: | We present a microchip technology for single-cell cytokine profiling of circulating CD34+ cells to detect abnormal hematopoietic stem/progenitor cells disseminated from patient bone marrow. It can stratify patients with different subtypes of myeloid diseases. A prospective cohort study (60 patients with myeloproliferative disease and 10 healthy donors) revealed three potential liquid biopsy biomarkers to distinguish fibrotic condition from non-fibrotic conditions, which has been a long-standing challenge in the field. © 2019 CBMS-0001. |
| Keywords: | myelofibrosis; hematopoietic stem cells; blood test; single-cell cytokine profiling |
| Journal Title | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
| Conference Dates: | 2019 Oct 27-31 |
| Conference Location: | Basel, Switzerland |
| ISBN: | 978-1-7334190-0-0 |
| Publisher: | Chemical and Biological Microsystems Society |
| Date Published: | 2019-01-01 |
| Start Page: | 492 |
| End Page: | 493 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 1 December 2020 -- Source: Scopus |
