Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma Journal Article
| Authors: | Eilber, F. C.; Brennan, M. F.; Eilber, F. R.; Eckardt, J. J.; Grobmyer, S. R.; Riedel, E.; Forscher, C.; Maki, R. G.; Singer, S. |
| Article Title: | Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma |
| Abstract: | PURPOSE: To determine if ifosfamide-based chemotherapy (IF) offers a survival benefit to adult patients with primary extremity synovial sarcoma. PATIENTS AND METHODS: Prospectively collected patient data from 2 institutions was used to identify all adult patients (≥16 years) with ≥5 cm, deep, primary, extremity, synovial sarcoma that underwent surgical treatment of cure from 1990 to 2002. A total of 101 patients were identified and the median follow-up for survivors was 58 months. Clinical, pathologic, and treatment variables were analyzed for disease-specific survival (DSS), distant recurrence-free survival (DRFS), and local recurrence-free survival (LRFS). RESULTS: Sixty-eight (67%) patients were treated with IF and 33 (33%) patients received no chemotherapy (NoC) for the primary tumor. The characteristics of the IF-treated patients [median tumor size = 7.2 cm; monophasic n = 46 (68%)] were similar to NoC patients [median tumor size = 7 cm; monophasic n = 23 (70%)]. The 4-year DSS of the IF-treated patients was 88% compared with 67% for the NoC patients (P = 0.01). Smaller size (HR = 0.3 per 5-cm decrease, P < 0.0001) and treatment with IF (HR = 0.3 compared with NoC, P = 0.007) were independently associated with an improved DSS. Treatment with IF was independently associated with an improved DRFS (HR = 0.4, P = 0.03) but not associated with an improved LRFS (P = 0.39). CONCLUSION: Ifosfamide-based chemotherapy was associated with an improved DSS in adult patients with high-risk, primary, extremity, synovial sarcoma and should be considered in the treatment of such patients. © 2007 Lippincott Williams & Wilkins, Inc. |
| Keywords: | adolescent; adult; cancer chemotherapy; cancer survival; controlled study; treatment outcome; aged; disease-free survival; middle aged; cancer surgery; survival rate; major clinical study; cisplatin; doxorubicin; adjuvant therapy; cancer patient; follow up; follow-up studies; prospective studies; dacarbazine; multiple cycle treatment; neoplasm recurrence, local; tumor volume; ifosfamide; antineoplastic agents, alkylating; limb tumor; mesna; synovial sarcoma; sarcoma, synovial; antibiotics, antineoplastic; leg; arm |
| Journal Title: | Annals of Surgery |
| Volume: | 246 |
| Issue: | 1 |
| ISSN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2007-07-01 |
| Start Page: | 105 |
| End Page: | 113 |
| Language: | English |
| DOI: | 10.1097/01.sla.0000262787.88639.2b |
| PUBMED: | 17592298 |
| PROVIDER: | scopus |
| PMCID: | PMC1899195 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 36" - "Export Date: 17 November 2011" - "CODEN: ANSUA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
1059Brennan -
18Grobmyer -
203Stubblefield -
238Maki -
337Singer
Related MSK Work