Proton MR spectroscopic imaging of the medulla and cervical spinal cord Journal Article
| Authors: | Edden, R. A. E.; Bonekamp, D.; Smith, M. A.; Dubey, P.; Barker, P. B. |
| Article Title: | Proton MR spectroscopic imaging of the medulla and cervical spinal cord |
| Abstract: | Purpose: To demonstrate the feasibility of quantitative, one-dimensional proton MR spectroscopic imaging (1D-MRSI) of the upper cervical spine and medulla at 3.0 Tesla. Materials and Methods: A method was developed for 1D-point-resolved spectroscopy sequence (PRESS)-MRSI, exciting signal in five voxels extending from the pontomedullary junction to the level of the C3 vertebra, and performed in 10 healthy volunteers to generate control data. Results: High-resolution 1D-MRSI data were obtained from all 10 subjects. Upper cervical spine concentrations of choline, creatine, and N-acetyl aspartate were estimated to be 2.8 ± 0.5. 8.8 ± 1.8, and 10.9 ± 2.7 mM, respectively, while in the medulla they were 2.6 ± 0.5, 9.1 ± 1.7, and 10.8 ± 0.9 mM. Conclusion: Quantitative 1D-MRSI of the upper cervical spine has been shown to be feasible at 3.0 Tesla. © 2007 Wiley-Liss, Inc. |
| Keywords: | adult; magnetic resonance imaging; metabolism; image analysis; diagnostic imaging; brain; quantitative analysis; spinal cord; spine; magnetic resonance spectroscopic imaging; magnetic resonance spectroscopy; choline; creatine; protons; image processing, computer-assisted; image processing; concentration (parameters); signal detection; n acetylaspartic acid; radiofrequency; normal human; proton nuclear magnetic resonance; human experiment; 3 tesla; nervous system diseases; cervical spine; cervical spinal cord; medulla; medulla oblongata; spectrophotometry |
| Journal Title: | Journal of Magnetic Resonance Imaging |
| Volume: | 26 |
| Issue: | 4 |
| ISSN: | 1053-1807 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2007-10-01 |
| Start Page: | 1101 |
| End Page: | 1105 |
| Language: | English |
| DOI: | 10.1002/jmri.21008 |
| PUBMED: | 17896355 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: JMRIF" - "Source: Scopus" |
