Histone deacetylase inhibitors: Overview and perspectives Journal Article
| Authors: | Dokmanovic, M.; Clarke, C.; Marks, P. A. |
| Article Title: | Histone deacetylase inhibitors: Overview and perspectives |
| Abstract: | Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a group of targeted anticancer agents. The first of these new HDACi, vorinostat (suberoylanilide hydroxamic acid), has received Food and Drug Administration approval for treating patients with cutaneous T-cell lymphoma. This review focuses on the activities of the 11 zinc-containing HDACs, their histone and nonhistone protein substrates, and the different pathways by which HDACi induce transformed cell death. A hypothesis is presented to explain the relative resistance of normal cells to HDACi-induced cell death. Copyright © 2007 American Association for Cancer Research. |
| Keywords: | unclassified drug; histone deacetylase inhibitor; itf 2357; clinical trial; fatigue; review; cisplatin; doxorubicin; fluorouracil; diarrhea; antineoplastic agents; clinical trials as topic; gemcitabine; paclitaxel; neoplasms; cell death; imatinib; carboplatin; unindexed drug; gene expression; anemia; etoposide; thrombocytopenia; combination chemotherapy; antineoplastic activity; drug effect; t cell lymphoma; enzyme regulation; drug mechanism; enzyme inhibitors; sulfonamide; vorinostat; trastuzumab; zinc; panobinostat; histone deacetylases; retinoid; 3 phenylsulfamoylcinnamohydroxamic acid; n (2 aminophenyl) 4 (3 pyridinylmethoxycarbonylaminomethyl)benzamide; pivaloyloxymethyl butyrate; 4 [n (2 hydroxyethyl) n [2 (3 indolyl)ethyl]aminomethyl]cinnamohydroxamic acid; sk 7041; sk 7068; depsipeptide; pci 24781; ellipticine; metalloproteins; 17 allylamino 17 demethoxygeldanamycin; fr 901228; if 2357; lbh 589; mgcd 0103; pdx 101 |
| Journal Title: | Molecular Cancer Research |
| Volume: | 5 |
| Issue: | 10 |
| ISSN: | 1541-7786 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2007-10-01 |
| Start Page: | 981 |
| End Page: | 989 |
| Language: | English |
| DOI: | 10.1158/1541-7786.mcr-07-0324 |
| PUBMED: | 17951399 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 175" - "Export Date: 17 November 2011" - "CODEN: MCROC" - "Source: Scopus" |
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