Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity Journal Article
| Authors: | Di Cristo, G.; Chattopadhyaya, B.; Kuhlman, S. J.; Fu, Y.; Bélanger, M. C.; Wu, C. Z.; Rutishauser, U.; Maffei, L.; Huang, Z. J. |
| Article Title: | Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity |
| Abstract: | Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here we show that polysialic acid (PSA), presented by the neural cell adhesion molecule, has a role in the maturation of GABAergic innervation and ocular dominance plasticity. Concentrations of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this decline is hindered by visual deprivation. The developmental and activity-dependent regulation of PSA expression is inversely correlated with the maturation of GABAergic innervation. Premature removal of PSA in visual cortex results in precocious maturation of perisomatic innervation by basket interneurons, enhanced inhibitory synaptic transmission, and earlier onset of ocular dominance plasticity. The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity. © 2007 Nature Publishing Group. |
| Keywords: | controlled study; protein expression; nonhuman; animal cell; mouse; animals; mice; animal tissue; animal experiment; animal model; age factors; precocious puberty; gene expression regulation, developmental; gabaergic system; interneuron; gamma-aminobutyric acid; glutamate decarboxylase; nerve cell adhesion molecule; polysialic acid; nerve cell plasticity; green fluorescent proteins; inhibition kinetics; animals, newborn; anesthetics, local; photic stimulation; analysis of variance; innervation; sialic acids; neuronal plasticity; evoked potentials, visual; glycoside hydrolases; neural cell adhesion molecules; synaptic transmission; neural inhibition; brain maturation; eye movement control; visual cortex; visual deprivation; critical period (psychology); sensory deprivation; tetrodotoxin; visual pathways |
| Journal Title: | Nature Neuroscience |
| Volume: | 10 |
| Issue: | 12 |
| ISSN: | 1097-6256 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2007-12-01 |
| Start Page: | 1569 |
| End Page: | 1577 |
| Language: | English |
| DOI: | 10.1038/nn2008 |
| PUBMED: | 18026099 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 34" - "Export Date: 17 November 2011" - "CODEN: NANEF" - "Source: Scopus" |
