Percutaneous computed tomography guided biopsy of sub-solid pulmonary nodules: differentiating solid from ground glass components at the time of biopsy Journal Article

Authors: Halpenny, D.; Das, K.; Ziv, E.; Plodkowski, A.; Zheng, J.; Capanu, M.; Rekhtman, N.; Montecalvo, J.; Solomon, S. B.; Ginsberg, M. S.
Article Title: Percutaneous computed tomography guided biopsy of sub-solid pulmonary nodules: differentiating solid from ground glass components at the time of biopsy
Abstract: Introduction: This study assessed (i) the ability to identify the solid components of part-solid nodules (PSN) during computed tomography (CT) guided lung biopsy (CTGLB), (ii) the ability of CTGLB to assess the invasive nature of a nodule on pathology. Materials and methods: Sixty-nine nodules were studied in 68 patients who underwent CTGLB between 1/1/2014 and 10/31/2015. Diagnostic CT images and CTGLB images were reviewed. On diagnostic CT images, nodules were classified as ground glass nodules (GGN) or PSNs. Nodule size, location, and percentage of solid component were recorded. At the time of biopsy, the ability to visualize the solid component of a PSN, depth of lesion from skin, and ability to identify the needle within the solid component were recorded. Results: There were 42 (61%) part-solid nodules and 27 (39%) GGNs. During biopsy, it was possible to differentiate the solid from the ground glass components in 35 (83%) PSNs. Fifty-nine (86%) nodules were neoplastic based on biopsy pathology (all non-small cell lung carcinoma). Thirty-nine (66%) were resected. In all cases biopsy pathology and surgical pathology agreed regarding the presence of lung carcinoma. In 6 (15%) cases biopsy pathology demonstrated purely lepidic growth but had some non-lepidic growth on surgical pathology, including 2 cases with acinar growth as a dominant pattern. Conclusion: In most patients, the solid and ground glass components of a PSN were distinguishable when performing a CTGLB. In a minority of patients, discrepancy was noted between biopsy pathology and surgical pathology regarding the invasive nature of a nodule. © 2020
Keywords: human tissue; aged; major clinical study; cancer growth; tumor localization; computer assisted tomography; tumor volume; cohort analysis; pathology; retrospective study; biopsy; lung adenocarcinoma; computerized tomography; surgery; lung carcinoma; glass; lung biopsy; pulmonary nodules; surgical pathology; biological organs; computed tomography; lung nodule; non small cell lung cancer; diagnostic ct; image guided biopsy; human; male; female; priority journal; article; percutaneous lung biopsy; solid components; part solid lung nodule; ground glass; ground glass nodules; non-small cell lung carcinomata; ground glass nodule; part solid nodule
Journal Title: Clinical Imaging
Volume: 69
ISSN: 0899-7071
Publisher: Elsevier Inc.  
Date Published: 2021-01-01
Start Page: 332
End Page: 338
Language: English
DOI: 10.1016/j.clinimag.2020.07.011
PUBMED: 33059184
PROVIDER: scopus
Notes: Article -- Export Date: 2 November 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. Junting Zheng
    157 Zheng
  2. Natasha Rekhtman
    295 Rekhtman
  3. Michelle S Ginsberg
    182 Ginsberg
  4. Marinela Capanu
    280 Capanu
  5. Stephen Solomon
    317 Solomon
  6. Etay   Ziv
    43 Ziv
  7. Krishna Kumar Das
    3 Das