Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse Journal Article
| Authors: | Brito, A.; Pereira, P. M. R.; Reis, R. L.; Ulijn, R. V.; Lewis, J. S.; Pires, R. A.; Pashkuleva, I. |
| Article Title: | Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse |
| Abstract: | Spheroids recapitulate the organization, heterogeneity and microenvironment of solid tumors. Herein, we targeted spatiotemporally the accelerated metabolism of proliferative cells located on the spheroid surface that ensure structure maintenance and/or growth. We demonstrate that phosphorylated carbohydrate amphiphile acts as a potent antimetabolite due to glycolysis inhibition and to in situ formation of supramolecular net around spheroid surface where alkaline phosphatase is overexpressed. The efficiency of the treatment is higher in spheroids as compared to the conventional 2D cultures because of the 2-fold higher expression of glucose transporter 1 (GLUT1). Moreover, treated spheroids do not undergo following relapse. © The Royal Society of Chemistry. |
| Keywords: | cell proliferation; alkaline phosphatase; carbohydrates; solid tumors; phosphatases; amphiphiles; microenvironments; cancer spheroid; glucose transporter-1; glycolysis inhibitions; in-situ formations; proliferative cells |
| Journal Title: | Nanoscale |
| Volume: | 12 |
| Issue: | 37 |
| ISSN: | 2040-3364 |
| Publisher: | Royal Society of Chemistry |
| Date Published: | 2020-10-07 |
| Start Page: | 19088 |
| End Page: | 19092 |
| Language: | English |
| DOI: | 10.1039/d0nr05008c |
| PUBMED: | 32955076 |
| PROVIDER: | scopus |
| PMCID: | PMC7541621 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2020 -- Source: Scopus |
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