The role of stereotactic biopsy in brain metastases Review
| Authors: | Yu, K. K. H.; Patel, A. R.; Moss, N. S. |
| Review Title: | The role of stereotactic biopsy in brain metastases |
| Abstract: | Brain metastases (BrM) affect up to 20% of patients with cancer and represent an increasing portion of patients with surgical brain tumors owing to improving prognoses of cancer patients in general and in many cases even of those with brain metastases. With advances in molecular biology and targeted therapy, the indications for neurosurgical sampling and specifically stereotactic biopsy are likely to change in the future. In this review the authors address some of the scientific advances in BrM biology, the clinical rationale and range of techniques currently used to perform stereotactic biopsy, and how the advent of molecular interrogation may potentially alter the way patients with BrM are managed in the future. © 2020 Elsevier Inc. |
| Keywords: | treatment response; unclassified drug; gene mutation; review; drug efficacy; nuclear magnetic resonance imaging; diagnostic accuracy; medical decision making; gene; ipilimumab; computer assisted tomography; breast cancer; image analysis; tumor volume; epidermal growth factor receptor; epidermal growth factor receptor 2; genetic association; protein p53; carcinogenesis; lung adenocarcinoma; gene rearrangement; diagnostic value; echography; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; blood brain barrier; brain metastasis; upregulation; stereotactic radiosurgery; cyclin dependent kinase inhibitor 2a; egfr gene; cyclin d1; b raf kinase; stereotactic biopsy; neuropathology; t cell factor protein; neratinib; lymphoid enhancer factor 1; small cell lung cancer; braf gene; anaplastic lymphoma kinase; metastatic melanoma; whole brain radiotherapy; wnt signaling; cyclin dependent kinase inhibitor 2b; peptides and proteins; trastuzumab emtansine; vemurafenib; pi3k/akt signaling; dabrafenib; ctnnb1 gene; alk gene; nivolumab; image guided biopsy; image-guided biopsy; human; priority journal; ceritinib; pembrolizumab; alectinib; abemaciclib; robot assisted surgery; brigatinib; lorlatinib; frameless stereotactic procedure; tucatinib; stereotactic techniques; hoxb protein |
| Journal Title: | Neurosurgery Clinics of North America |
| Volume: | 31 |
| Issue: | 4 |
| ISSN: | 1042-3680 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2020-10-01 |
| Start Page: | 515 |
| End Page: | 526 |
| Language: | English |
| DOI: | 10.1016/j.nec.2020.06.002 |
| PUBMED: | 32921348 |
| PROVIDER: | scopus |
| PMCID: | PMC7490462 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 October 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work