Resting-state functional connectivity in early postanaesthesia recovery is characterised by globally reduced anticorrelations Journal Article
| Authors: | Nir, T.; Jacob, Y.; Huang, K. H.; Schwartz, A. E.; Brallier, J. W.; Ahn, H.; Kundu, P.; Tang, C. Y.; Delman, B. N.; McCormick, P. J.; Sano, M.; Deiner, S.; Baxter, M. G.; Mincer, J. S. |
| Article Title: | Resting-state functional connectivity in early postanaesthesia recovery is characterised by globally reduced anticorrelations |
| Abstract: | Background: A growing body of literature addresses the possible long-term cognitive effects of anaesthetics, but no study has delineated the normal trajectory of neural recovery attributable to anaesthesia alone in adults. We obtained resting-state functional MRI scans on 72 healthy human volunteers between ages 40 and 80 (median: 59) yr before, during, and after general anaesthesia with sevoflurane, in the absence of surgery, as part of a larger study on cognitive function postanaesthesia. Methods: Region-of-interest analysis, independent component analysis, and seed-to-voxel analysis were used to characterise resting-state functional connectivity and to differentiate between correlated and anticorrelated connectivity before, during, and after general anaesthesia. Results: Whilst positively correlated functional connectivity remained essentially unchanged across these perianaesthetic states, anticorrelated functional connectivity decreased globally by 35% 1 h after emergence from general anaesthesia compared with baseline, as seen by the region-of-interest analysis. This decrease corresponded to a consistent reduction in expression of canonical resting-state networks, as seen by independent component analysis. All measures returned to baseline 1 day later. Conclusions: The normal perianaesthesia trajectory of resting-state connectivity in healthy adults is characterised by a transient global reduction in anticorrelated activity shortly after emergence from anaesthesia that returns to baseline by the following day. Clinical trial registration: NCT02275026. © 2020 British Journal of Anaesthesia |
| Keywords: | mri; functional mri; consciousness; recovery; functional connectivity; general anaesthesia |
| Journal Title: | British Journal of Anaesthesia |
| Volume: | 125 |
| Issue: | 4 |
| ISSN: | 0007-0912 |
| Publisher: | Oxford University Press |
| Date Published: | 2020-10-01 |
| Start Page: | 529 |
| End Page: | 538 |
| Language: | English |
| DOI: | 10.1016/j.bja.2020.06.058 |
| PUBMED: | 32800503 |
| PROVIDER: | scopus |
| PMCID: | PMC7565909 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 October 2020 -- Source: Scopus |
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