Decreased hand motor resting-state functional connectivity in patients with glioma: Analysis of factors including neurovascular uncoupling Journal Article
| Authors: | Sun, H.; Vachha, B.; Laino, M. E.; Jenabi, M.; Flynn, J. R.; Zhang, Z.; Holodny, A. I.; Peck, K. K. |
| Article Title: | Decreased hand motor resting-state functional connectivity in patients with glioma: Analysis of factors including neurovascular uncoupling |
| Abstract: | Background: Resting-state functional MRI holds substantial potential for clinical application, but limitations exist in current understanding of how tumors exert local effects on resting-state functional MRI readings. Purpose: To investigate the association between tumors, tumor characteristics, and changes in resting-state connectivity, to explore neurovascular uncoupling as a mechanism underlying these changes, and to evaluate seeding methodologies as a clinical tool. Materials and Methods: Institutional review board approval was obtained for this HIPAA-compliant observational retrospective study of patients with glioma who underwent MRI and resting-state functional MRI between January 2016 and July 2017. Interhemispheric symmetry of connectivity was assessed in the hand motor region, incorporating tumor position, perfusion, grade, and connectivity generated from seed-based correlation. Statistical analysis was performed by using one-tailed t tests, Wilcoxon rank sum tests, one-way analysis of variance, Pearson correlation, and Spearman rank correlation, with significance at P , .05. Results: Data in a total of 45 patients with glioma (mean age, 51.3 years 6 14.3 [standard deviation]) were compared with those in 10 healthy control subjects (mean age, 50.3 years 6 17.2). Patients showed loss of symmetry in measures of hand motor resting-state connectivity compared with control subjects (P , .05). Tumor distance from the ipsilateral hand motor (IHM) region correlated with the degree (R = 0.38, P = .01) and strength (R = 0.33, P = .03) of resting-state connectivity. In patients with World Health Organization grade IV glioblastomas 40 mm or less from the IHM region, loss of symmetry in strength of resting-state connectivity was correlated with tumor perfusion (R = 0.74, P , .01). In patients with gliomas 40 mm or less from the IHM region, seeding the nontumor hemisphere yielded less asymmetric hand motor resting-state connectivity than seeding the tumor hemisphere (connectivity seeded:contralateral = 1.34 nontumor vs 1.38 tumor hemisphere seeded; P = .03, false discovery rate threshold = 0.01). Conclusion: Hand motor resting-state connectivity was less symmetrical in a tumor distance–dependent manner in patients with glioma. Differences in resting-state connectivity may be false-negative results driven by a neurovascular uncoupling mechanism. Seeding from the nontumor hemisphere may attenuate asymmetry in patients with tumors near ipsilateral hand motor cortices. © RSNA, 2020 |
| Journal Title: | Radiology |
| Volume: | 294 |
| Issue: | 3 |
| ISSN: | 0033-8419 |
| Publisher: | Radiological Society of North America, Inc. |
| Date Published: | 2020-03-01 |
| Start Page: | 610 |
| End Page: | 621 |
| Language: | English |
| DOI: | 10.1148/radiol.2019190089 |
| PUBMED: | 31934827 |
| PROVIDER: | scopus |
| PMCID: | PMC7051163 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 April 2020 -- Source: Scopus |
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